Therapeutic Applications for Oncolytic Self-Replicating RNA Viruses
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415622
Abstract: Self-replicating RNA viruses have become attractive delivery vehicles for therapeutic applications. They are easy to handle, can be rapidly produced in large quantities, and can be delivered as recombinant viral particles, naked or nanoparticle-encapsulated RNA,… read more here.
Keywords: self replicating; replicating rna; therapeutic applications; rna viruses ... See more keywords
Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and Cancer
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DOI: 10.3390/vaccines9101187
Abstract: Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-stranded RNA viruses, which have been engineered for recombinant protein expression and vaccine development. Due to the presence of RNA-dependent RNA polymerase activity, subgenomic RNA can replicate… read more here.
Keywords: replicating rna; rna viruses; self replicating; cancer ... See more keywords
SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern
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DOI: 10.7554/elife.75537
Abstract: Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing… read more here.
Keywords: replicating rna; sars cov2; cov2 variants; variants concern ... See more keywords