The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14406
Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.
Keywords: bccip; dna; nascent dna; replication ... See more keywords
The bacterial MRE11-RAD50 and DNA2-WRN homologs process replication forks at distinct and separate loci on the chromosome.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS letters"
DOI: 10.1002/1873-3468.70211
Abstract: Human BRCA2 protects the DNA when replication forks stall, whereas MRE11-RAD50 and DNA2-WRN process or partially degrade these substrates. When mutated, these genes result in distinct genetic instabilities and cancers, arguing they have unique, not… read more here.
Keywords: replication; process; dna2 wrn; replication forks ... See more keywords
PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13433
Abstract: Oncogene-induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common cause of replication stress… read more here.
Keywords: replication; overexpression; ppm1d; activity ... See more keywords
MND1 enables homologous recombination in somatic cells primarily outside the context of replication.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13448
Abstract: Faithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of DSBs in somatic cells. We… read more here.
Keywords: recombination; mnd1 enables; replication; mnd1 ... See more keywords
SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus
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DOI: 10.1002/advs.202203088
Abstract: Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing… read more here.
Keywords: replication; srsf5; host; virus ... See more keywords
Lung‐Targeted Lipid Nanoparticle‐Delivered siUSP33 Attenuates SARS‐CoV‐2 Replication and Virulence by Promoting Envelope Degradation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406211
Abstract: As a structural protein of SARS‐CoV‐2, the envelope (E) protein not only plays a key role in the formation of viral particles, but also forms ion channels and has pathogenic functions, including triggering cell death… read more here.
Keywords: sars cov; replication; replication virulence; envelope ... See more keywords
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
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DOI: 10.1002/advs.202407695
Abstract: Reactive oxygen species (ROS) of hosts are widely involved in intracellular signaling and against pathogens. Viruses manipulate ROS homeostasis of hosts as a strategy to evade ROS‐mediated negative effects of their infection, but the mechanisms… read more here.
Keywords: replication; viral replication; shrimp; ros dynamics ... See more keywords
DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication
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DOI: 10.1002/advs.202409485
Abstract: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence, however, how the host innate immune system responds to cccDNA is still less known. Here, based on cccDNA‐hepatic proteins interaction… read more here.
Keywords: replication; dna sensor; hepatitis virus; cccdna inhibit ... See more keywords
A Novel Protein NLRP12‐119aa that Prevents Rhabdovirus Replication by Disrupting the RNP Complex Formation
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DOI: 10.1002/advs.202409953
Abstract: The accurate assembly of the ribonucleoprotein (RNP) complex is fundamental for the replication and transcription of rhabdoviruses, which are known for their broad pathogenic impact. A novel 119‐amino‐acid protein, NLRP12‐119aa is identified, encoded by the… read more here.
Keywords: replication; protein; nlrp12 119aa; formation ... See more keywords
PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation
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DOI: 10.1002/advs.202503487
Abstract: Virus infection stimulates proto‐oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity during human coronavirus HCoV‐OC43 infection.… read more here.
Keywords: innate immunity; replication; pim1; ifnar1 degradation ... See more keywords
Challenging endings: How telomeres prevent fragility
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DOI: 10.1002/bies.202100157
Abstract: It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly… read more here.
Keywords: fragility; prevent fragility; telomeres prevent; challenging endings ... See more keywords