The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14406
Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.
Keywords: bccip; dna; nascent dna; replication ... See more keywords
PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13433
Abstract: Oncogene-induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common cause of replication stress… read more here.
Keywords: replication; overexpression; ppm1d; activity ... See more keywords
MND1 enables homologous recombination in somatic cells primarily outside the context of replication.
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DOI: 10.1002/1878-0261.13448
Abstract: Faithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of DSBs in somatic cells. We… read more here.
Keywords: recombination; mnd1 enables; replication; mnd1 ... See more keywords
SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus
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DOI: 10.1002/advs.202203088
Abstract: Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing… read more here.
Keywords: replication; srsf5; host; virus ... See more keywords
Challenging endings: How telomeres prevent fragility
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DOI: 10.1002/bies.202100157
Abstract: It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly… read more here.
Keywords: fragility; prevent fragility; telomeres prevent; challenging endings ... See more keywords
Rad53 arrests leading and lagging strand DNA synthesis via distinct mechanisms in response to DNA replication stress
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DOI: 10.1002/bies.202200061
Abstract: DNA replication stress threatens ordinary DNA synthesis. The evolutionarily conserved DNA replication stress response pathway involves sensor kinase Mec1/ATR, adaptor protein Mrc1/Claspin, and effector kinase Rad53/Chk1, which spurs a host of changes to stabilize replication… read more here.
Keywords: replication stress; dna synthesis; replication; dna ... See more keywords
DNA replication timing: Biochemical mechanisms and biological significance
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DOI: 10.1002/bies.202200097
Abstract: The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the… read more here.
Keywords: replication; replication timing; timing biochemical; timing regulated ... See more keywords
Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability
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DOI: 10.1002/bies.202200141
Abstract: DNAreplicationduringthesynthesis(S-)phaseofthecellcycleisakey step in cell proliferation. DNA replication fidelity and cell cycle checkpoints ensure that transient DNA damage is not converted into stable mutations.Thesedirectlinkstocellproliferationandmutationalavoid-ancemakeDNAreplicationcheckpointsimportanttogenomestability. He and Zhang’s Hypothesis explores how DNA replication complexes are maintained during… read more here.
Keywords: strands together; dna; replication; fork ... See more keywords
ORChestra coordinates the replication and repair music
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DOI: 10.1002/bies.202200229
Abstract: Error‐free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP‐dependent manner, play critical roles in… read more here.
Keywords: replication repair; replication; orchestra coordinates; repair music ... See more keywords
Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS‐CoV‐2 Replication Complex **
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DOI: 10.1002/cbic.202300095
Abstract: SARS‐CoV‐2 causes individualized symptoms. Many reasons have been given. We propose that an individual's epitranscriptomic system could be responsible as well. The viral RNA genome can be subject to epitranscriptomic modifications, which can be different… read more here.
Keywords: activity sars; replication; m1a; cov replication ... See more keywords
A troubling lack of replicability for cancer biology studies
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DOI: 10.1002/cncy.22639
Abstract: K AT E R Y N A K O N / S H U TT E R S TO C K .C O M I n November 2021, a collaborative effort called the Reproducibility Project:… read more here.
Keywords: research; replicability; replication; cancer biology ... See more keywords