Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.02.003
Abstract: When Fanconi Anemia (FA) proteins were depleted in human U2OS cells with integrated DNA repair reporters, we observed decreases in homologous recombination (HR), decreases in mutagenic non-homologous end joining (m-NHEJ) and increases in canonical NHEJ,… read more here.
Keywords: end joining; fanconi anemia; homologous end; replication associated ... See more keywords
Plasmid replication-associated single-strand-specific methyltransferases
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1163
Abstract: Abstract Analysis of genomic DNA from pathogenic strains of Burkholderia cenocepacia J2315 and Escherichia coli O104:H4 revealed the presence of two unusual MTase genes. Both are plasmid-borne ORFs, carried by pBCA072 for B. cenocepacia J2315… read more here.
Keywords: plasmid replication; dna; strand; replication associated ... See more keywords
Abstract 2771: KSQ-4279 mediated USP1 inhibition induces replication associated DNA gaps that contribute to cell death
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2771
Abstract: Tumors with defects in DNA double strand break (DSB) repair pathways, including those with mutations in BRCA1/2, are often treated with either poly (ADP-ribose) polymerase-1 (PARP1) inhibitors or platinum-based chemotherapy. Despite their clinical benefits, many… read more here.
Keywords: ksq 4279; ksq; dna gaps; replication associated ... See more keywords
Proline-specific aminopeptidase P prevents replication-associated genome instability
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DOI: 10.1371/journal.pgen.1010025
Abstract: Genotoxic stress during DNA replication constitutes a serious threat to genome integrity and causes human diseases. Defects at different steps of DNA metabolism are known to induce replication stress, but the contribution of other aspects… read more here.
Keywords: associated genome; replication associated; prevents replication; genome instability ... See more keywords
The Role of Replication-Associated Repair Factors on R-Loops
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DOI: 10.3390/genes8070171
Abstract: The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication processes… read more here.
Keywords: repair factors; dna; replication associated; role ... See more keywords