Checkpoint functions of RecQ helicases at perturbed DNA replication fork.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-020-01147-y
Abstract: DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains… read more here.
Keywords: dna replication; recq helicases; functions recq; replication checkpoint ... See more keywords
Replication Catastrophe: When a Checkpoint Fails because of Exhaustion.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.05.001
Abstract: Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly completion of genome duplication, and its malfunction may lead to catastrophic genome disruption, including unscheduled firing of replication origins, stalling and collapse of… read more here.
Keywords: replication catastrophe; replication checkpoint; checkpoint; catastrophe checkpoint ... See more keywords
Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00033-20
Abstract: Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However,… read more here.
Keywords: instability; replication; cds1; replication checkpoint ... See more keywords
RecQ DNA Helicase Rqh1 Promotes Rad3ATR Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00145-20
Abstract: Rad3 is the orthologue of ATR and the sensor kinase of the DNA replication checkpoint in Schizosaccharomyces pombe. Under replication stress, it initiates checkpoint signaling at the forks necessary for maintaining genome stability and cell… read more here.
Keywords: checkpoint; replication; dna replication; helicase ... See more keywords