Rational Design of a Replication-Competent and Inheritable Magnetic Viruses for Targeting Biomedical Applications.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202002435
Abstract: Infection with live-attenuated vaccines always inevitably induces side effects that reduce their safety. This study suggests a concept of magnetic virus produced by genetically modifying viral surfaces with Fe3 O4 nanoparticles (NPs) to control their… read more here.
Keywords: ev71; rational design; ev71 fe3; replication competent ... See more keywords
Establishment of Replication-Competent HCV Strain with Minimum Modifications.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8976-8_4
Abstract: The HCV cell culture system, consisting of the JFH-1 strain and HuH-7 cells, has been broadly used to assess the complete HCV life cycle in cultured cells. However, being able to use multiple HCV strains… read more here.
Keywords: strain; competent hcv; hcv; replication competent ... See more keywords
The Alphabet Soup of HIV Reservoir Markers
Sign Up to like & getrecommendations! Published in 2017 at "Current HIV/AIDS Reports"
DOI: 10.1007/s11904-017-0355-y
Abstract: Purpose of ReviewDespite the success of antiretroviral therapy in suppressing HIV, life-long therapy is required to avoid HIV reactivation from long-lived viral reservoirs. Currently, there is intense interest in searching for therapeutic interventions that can… read more here.
Keywords: reservoir; viral reservoir; hiv; replication competent ... See more keywords
Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.12.009
Abstract: The beta (β)-cell mass formed during embryogenesis is amplified by cell replication during fetal and early postnatal development. Thereafter, β cells become functionally mature, and their mass is maintained by a low rate of replication.… read more here.
Keywords: cell; replication competent; responsive replication; lif responsive ... See more keywords
Construction of replication-competent oncolytic retroviral vectors expressing R peptide-truncated 10A1 envelope glycoprotein.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2019.03.008
Abstract: Replication-deficient retroviral (RDR) vectors have been generally used for gene therapy, but clinically beneficial transduction efficiency is difficult to achieve with these vectors. In recent times, attention has been focused on the use of murine… read more here.
Keywords: momlv 10a1; mlv; replication competent; gene ... See more keywords
Inactivation of Replication-Competent SARS-CoV-2 on Common Surfaces by Disinfectants.
Sign Up to like & getrecommendations! Published in 2022 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2021.527
Abstract: This experimental laboratory-based study evaluated two disinfectants' efficacy against replication-competent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on three surfaces. Disinfectants were efficacious at eliminating the presence, viability, and subsequent replication of SARS-CoV-2 on all surfaces.… read more here.
Keywords: surfaces disinfectants; replication; inactivation replication; replication competent ... See more keywords
Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00319
Abstract: In the fight against antimicrobial resistance, bacteriophages are a promising alternative to antibiotics. However, due to their narrow spectra, phage therapy requires the careful matching between the host and bacteriophage to be effective. Despite our… read more here.
Keywords: host specificity; specificity; replication competent; host ... See more keywords
Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2016.68
Abstract: The fast proliferation of tumor cells develops faster than the vasculature, resulting, in most malignant tumors, in generation of hypoxic regions. Hypoxia renders solid tumors resistant to radiation and chemotherapeutics while providing opportunities for tumor-selective… read more here.
Keywords: hif; hif hif; creb; replication competent ... See more keywords
Short Communication: Potential Risk of Replication-Competent Virus in HIV-1 Env-Pseudotyped Virus Preparations
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2016.0142
Abstract: Abstract Env-pseudotyped viruses are valuable reagents for studies of HIV-1 neutralizing antibodies. It is often assumed that all pseudovirus particles are capable of only a single round of infection, making them a safe alternative to… read more here.
Keywords: hiv; virus; env pseudotyped; replication competent ... See more keywords
Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000001797
Abstract: Abstract Many seminal advances have been made in human immunodeficiency virus (HIV)/AIDS research over the past four decades. Treatment strategies, such as gene therapy and immunotherapy, are yielding promising results to effectively control HIV infection.… read more here.
Keywords: hiv; replication competent; strategy; host cells ... See more keywords
Tracking the Replication-Competent Zika Virus with Tetracysteine-Tagged Capsid Protein in Living Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01846-21
Abstract: Zika virus (ZIKV) is the mosquito-borne enveloped flavivirus that causes microcephaly in neonates. While real-time imaging plays a critical role in dissecting viral biology, no fluorescent, genetically engineered ZIKV for single-particle tracking is currently available.… read more here.
Keywords: replication competent; capsid protein; virus; zikv ... See more keywords