Histones H3 and H4 require their relevant amino-tails for efficient nuclear import and replication-coupled chromatin assembly in vivo
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DOI: 10.1038/s41598-017-03218-6
Abstract: Concomitant chromatin assembly and DNA duplication is essential for cell survival and genome integrity, and requires newly synthesized histones. Although the N-terminal domains of newly synthesized H3 and H4 present critical functions, their requirement for… read more here.
Keywords: chromatin; coupled chromatin; chromatin assembly; replication coupled ... See more keywords
AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13438
Abstract: Minichromosome Maintenance protein 10 (MCM10) is essential for DNA replication initiation and DNA elongation in yeasts and animals. Although the functions of MCM10 in DNA replication and repair have been well documented, the detail mechanisms… read more here.
Keywords: atmcm10; replication; replication coupled; nucleosome assembly ... See more keywords
Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication-coupled histone incorporation
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DOI: 10.1126/sciadv.adu6799
Abstract: Stem cells display asymmetric histone inheritance, while nonstem progenitor cells exhibit symmetric patterns in the Drosophila male germ line. Here, we report that components involved in lagging strand synthesis, DNA polymerases α and δ, have… read more here.
Keywords: replication; stem; replication coupled; coupled histone ... See more keywords
RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly
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DOI: 10.1126/science.aah4712
Abstract: The platform for building new chromatin Nucleosomes removed from DNA to facilitate its replication must be replaced quickly to protect the genome. The epigenetic information stored on the parental nucleosomes must also be preserved on… read more here.
Keywords: dna replication; stranded dna; replication coupled; nucleosome assembly ... See more keywords
Abstract IA016: Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms
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DOI: 10.1158/1538-7445.dnarepair24-ia016
Abstract: Single strand breaks (SSBs), including DNA nicks, are the most common form of endogenous DNA damage. If they are not resolved before the passage of a replication fork, current models suggest that SSBs are converted… read more here.
Keywords: replication; strand; replication coupled; strand breaks ... See more keywords
The Role of Histone Modification in DNA Replication-Coupled Nucleosome Assembly and Cancer
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DOI: 10.3390/ijms24054939
Abstract: Histone modification regulates replication-coupled nucleosome assembly, DNA damage repair, and gene transcription. Changes or mutations in factors involved in nucleosome assembly are closely related to the development and pathogenesis of cancer and other human diseases… read more here.
Keywords: replication coupled; histone modification; nucleosome assembly; modification ... See more keywords