Development of a replication‐deficient adenoviral vector‐based vaccine candidate for the interception of HPV16‐ and HPV18‐induced infections and disease
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30679
Abstract: High‐risk Human papilloma virus (HPV) types are the causative agents of cervical cancer and several other anogenital malignancies. The viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. Many approaches… read more here.
Keywords: replication deficient; hpv16 hpv18; vaccine candidate; disease ... See more keywords
A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment
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DOI: 10.1038/s41541-024-00908-x
Abstract: Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved vaccines for Epstein-Barr… read more here.
Keywords: replication; gammaherpesvirus; disease; replication deficient ... See more keywords
A novel replication-deficient FCV vaccine provides strong immune protection in cats
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.00093-25
Abstract: ABSTRACT Feline calicivirus (FCV) belongs to the family Caliciviridae, which includes important animal and human pathogens such as human norovirus and rabbit hemorrhagic disease virus. The fast evolution and great diversity of FCV make it… read more here.
Keywords: fcv; replication; genetics; replication deficient ... See more keywords
A Respiratory Syncytial Virus Vaccine Vectored by a Stable Chimeric and Replication-Deficient Sendai Virus Protects Mice without Inducing Enhanced Disease
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DOI: 10.1128/jvi.02298-16
Abstract: ABSTRACT Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people, and no marketed vaccine exists. In this study, we generated and analyzed a subunit vaccine against RSV… read more here.
Keywords: replication deficient; rsv; respiratory; vaccine ... See more keywords
Replication-Deficient Zika Vector-Based Vaccine Provides Maternal and Fetal Protection in Mouse Model
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DOI: 10.1128/spectrum.01137-22
Abstract: This research is important as it strives to address the critical need for effective prophylactic measures against the outbreak of Zika virus (ZIKV) and outlines an important vaccine technology that could potentially be used to… read more here.
Keywords: replication; vector; zikv; vaccine ... See more keywords
Replication-Deficient Lymphocytic Choriomeningitis Virus-Vectored Vaccine Candidate for the Induction of T Cell Immunity against Mycobacterium tuberculosis
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DOI: 10.3390/ijms23052700
Abstract: Mycobacterium tuberculosis (Mtb) represents a major burden to global health, and refined vaccines are needed. Replication-deficient lymphocytic choriomeningitis virus (rLCMV)-based vaccine vectors against cytomegalovirus have proven safe for human use and elicited robust T cell… read more here.
Keywords: replication deficient; rlcmv; mycobacterium tuberculosis; cell ... See more keywords
Packaging, Purification, and Titration of Replication-Deficient Semliki Forest Virus-Derived Particles as a Self-Amplifying mRNA Vaccine Vector
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Biomedical Journal"
DOI: 10.52547/ibj.3535
Abstract: Background: Self-amplifying mRNA is the next-generation vaccine platform with the potential advantages in efficacy and speed of development against infectious diseases and cancer. The main aim was to present optimized and rapid methods for SFV-PD… read more here.
Keywords: self amplifying; vaccine; replication deficient; packaging ... See more keywords