HIV-1 usurps transcription start site heterogeneity of host RNA polymerase II to maximize replication fitness.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2305103120
Abstract: HIV-1 relies on host RNA polymeraseII (Pol II) to transcribe its genome and uses multiple transcription start sites (TSS), including three consecutive guanosines located near the U3-R junction, to generate transcripts containing three, two, and… read more here.
Keywords: replication fitness; hiv; transcription; replication ... See more keywords
Selection of Multi-Drug Resistant Influenza A and B Viruses under Zanamivir Pressure and their Replication Fitness in Ferrets
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Therapy"
DOI: 10.3851/imp3135
Abstract: Background Intravenous zanamivir has been used to treat patients with severe influenza. Because the majority of cases (including immunocompromised patients) require the drug for an extended period of treatment, there is a higher risk that… read more here.
Keywords: replication fitness; influenza; drug; zanamivir pressure ... See more keywords