Pioneer factors for DNA replication initiation in metazoans
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DOI: 10.1002/bies.202400002
Abstract: Precise DNA replication is fundamental for genetic inheritance. In eukaryotes, replication initiates at multiple origins that are first “licensed” and subsequently “fired” to activate DNA synthesis. Despite the success in identifying origins with specific DNA… read more here.
Keywords: replication; dna replication; pioneer factors; factors dna ... See more keywords
DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
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DOI: 10.1038/s41467-024-55148-3
Abstract: The rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in… read more here.
Keywords: replication; initiation; drives focal; replication initiation ... See more keywords
Mechanisms and regulation of DNA replication initiation in eukaryotes
Sign Up to like & getrecommendations! Published in 2017 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2016.1274717
Abstract: Abstract Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins) and facilitate duplex DNA melting within these regions. In a typical cell cycle,… read more here.
Keywords: mechanisms regulation; dna; dna replication; replication initiation ... See more keywords
The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad277
Abstract: Abstract Genome replication is a fundamental biological activity shared by all organisms. Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two helicases, one for each replisome. However, the molecular mechanisms underpinning helicase loading… read more here.
Keywords: dna; replication; dnad; replication initiation ... See more keywords
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
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DOI: 10.1101/2024.10.06.616894
Abstract: In Escherichia coli, replisome and replication fork assembly is initiated by DnaB helicase loading at the chromosomal origin oriC via its interactions with the DnaA initiator and the DnaC helicase loader. Upon replication fork arrest,… read more here.
Keywords: replication; initiation; helicase; replication initiation ... See more keywords
DNA replication initiation shapes the mutational landscape and expression of the human genome
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DOI: 10.1126/sciadv.add3686
Abstract: The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and… read more here.
Keywords: human genome; dna; replication; expression ... See more keywords
Mechanisms for initiating cellular DNA replication
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aah6317
Abstract: Diverse molecular choreography of replication Accurate duplication and transmission of genetic information to the next generation requires complex molecular assemblies. Bleichert et al. review replication initiation across the three domains of life, with a focus… read more here.
Keywords: dna; dna replication; replication initiation; helicase ... See more keywords
DNA replication initiation timing is important for maintaining genome integrity
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Bacteriology"
DOI: 10.1128/jb.00175-25
Abstract: ABSTRACT DNA replication is regulated by factors that promote or inhibit initiation. In Bacillus subtilis, YabA is a negative regulator of replication initiation, while the newly identified kinase CcrZ is a positive regulator. The consequences… read more here.
Keywords: replication; replication initiation; dna replication; cells initiating ... See more keywords
The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC
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DOI: 10.1128/mbio.01330-19
Abstract: To survive bouts of starvation, cells must inhibit DNA replication. In bacteria, starvation triggers production of a signaling molecule called ppGpp (guanosine tetraphosphate) that helps reprogram cellular physiology, including inhibiting new rounds of DNA replication.… read more here.
Keywords: initiation; replication; ppgpp; dna replication ... See more keywords
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
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DOI: 10.1186/s13059-025-03591-w
Abstract: Background The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using BrdU incorporation and single-molecule nanopore sequencing. Results… read more here.
Keywords: replication; dna replication; initiation; initiation events ... See more keywords
A novel replication initiation region encoded in a widespread Acinetobacter plasmid lineage carrying a blaNDM-1 gene
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DOI: 10.1371/journal.pone.0303976
Abstract: The blaNDM-1 gene and its variants encode metallo-beta-lactamases that confer resistance to almost all beta-lactam antibiotics. Genes encoding blaNDM-1 and its variants can be found in several Acinetobacter species, and they are usually linked to… read more here.
Keywords: replication; blandm gene; replication initiation; acinetobacter ... See more keywords