Mechanisms and regulation of DNA replication initiation in eukaryotes
Sign Up to like & getrecommendations! Published in 2017 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2016.1274717
Abstract: Abstract Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins) and facilitate duplex DNA melting within these regions. In a typical cell cycle,… read more here.
Keywords: mechanisms regulation; dna; dna replication; replication initiation ... See more keywords
The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad277
Abstract: Abstract Genome replication is a fundamental biological activity shared by all organisms. Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two helicases, one for each replisome. However, the molecular mechanisms underpinning helicase loading… read more here.
Keywords: dna; replication; dnad; replication initiation ... See more keywords
DNA replication initiation shapes the mutational landscape and expression of the human genome
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DOI: 10.1126/sciadv.add3686
Abstract: The interplay between active biological processes and DNA repair is central to mutagenesis. Here, we show that the ubiquitous process of replication initiation is mutagenic, leaving a specific mutational footprint at thousands of early and… read more here.
Keywords: human genome; dna; replication; expression ... See more keywords
Mechanisms for initiating cellular DNA replication
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aah6317
Abstract: Diverse molecular choreography of replication Accurate duplication and transmission of genetic information to the next generation requires complex molecular assemblies. Bleichert et al. review replication initiation across the three domains of life, with a focus… read more here.
Keywords: dna; dna replication; replication initiation; helicase ... See more keywords
The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC
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DOI: 10.1128/mbio.01330-19
Abstract: To survive bouts of starvation, cells must inhibit DNA replication. In bacteria, starvation triggers production of a signaling molecule called ppGpp (guanosine tetraphosphate) that helps reprogram cellular physiology, including inhibiting new rounds of DNA replication.… read more here.
Keywords: initiation; replication; ppgpp; dna replication ... See more keywords
DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression
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DOI: 10.1534/genetics.115.186627
Abstract: Proper control of DNA replication is critical to ensure genomic integrity during cell proliferation. In addition, differential regulation of the DNA replication program during development can change gene copy number to influence cell size and… read more here.
Keywords: control; dna replication; replication initiation; initiation fork ... See more keywords
The Role of MTBP as a Replication Origin Firing Factor
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11060827
Abstract: Simple Summary Copying the chromosomal DNA completely and faithfully during the process of DNA replication is key to inheriting the genetic information in an unaltered state. To achieve this, replication initiation, which generates the complex… read more here.
Keywords: replication; replication initiation; origin firing; initiation ... See more keywords
NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108724
Abstract: Alpha-aminoterminal acetyltransferase B (NatB) is a critical enzyme responsible for acetylating the aminoterminal end of proteins, thereby modifying approximately 21% of the proteome. This post-translational modification impacts protein folding, structure, stability, and interactions between proteins… read more here.
Keywords: catalytic subunit; replication; cell cycle; replication initiation ... See more keywords
Nucleosomes influence multiple steps during replication initiation
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22512
Abstract: Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct… read more here.
Keywords: replication initiation; activation; steps replication; origin licensing ... See more keywords