Hypoxic microenvironment shapes HIV-1 replication and latency
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1103-1
Abstract: Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary… read more here.
Keywords: hiv replication; replication; oxygen; replication latency ... See more keywords
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency
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DOI: 10.1371/journal.ppat.1008037
Abstract: Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirus (CMV), regulates epidermal growth factor receptor (EGFR), upstream of PI3K, to… read more here.
Keywords: egfr; latency; replication latency; egfr signaling ... See more keywords
HIV-1 replication and latency are balanced by mTOR-driven cell metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1068436
Abstract: Human Immunodeficiency virus type 1 (HIV-1) relies on host cell metabolism for all aspects of viral replication. Efficient HIV-1 entry, reverse transcription, and integration occurs in activated T cells because HIV-1 proteins co-opt host metabolic… read more here.
Keywords: replication latency; metabolism; mtor; cell metabolism ... See more keywords
Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency
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DOI: 10.3390/v14020287
Abstract: Visualization of the herpesvirus genomes during lytic replication and latency is mainly achieved by fluorescence in situ hybridization (FISH). Unfortunately, this technique cannot be used for the real-time detection of viral genome in living cells.… read more here.
Keywords: replication latency; visualization; replication; lytic replication ... See more keywords