Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
Sign Up to like & getrecommendations! Published in 2017 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2016.04.006
Abstract: As regulators of bioenergetics in the cell and the primary source of endogenous reactive oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the process of aging and age-related diseases. Mitochondrial DNA (mtDNA)… read more here.
Keywords: replication machinery; age related; aging age; dna ... See more keywords
The architecture and function of the chromatin replication machinery.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.03.011
Abstract: Genomic DNA in eukaryotic cells is packaged into nucleosome arrays. During replication, nucleosomes need to be dismantled ahead of the advancing replication fork and reassembled on duplicated DNA. The architecture and function of the core… read more here.
Keywords: replication machinery; machinery; dna; replication ... See more keywords
Capping pores of alphavirus nsP1 gate membranous viral replication factories
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DOI: 10.1038/s41586-020-3036-8
Abstract: Positive-sense single-stranded RNA viruses, such as coronaviruses, flaviviruses and alphaviruses, carry out transcription and replication inside virus-induced membranous organelles within host cells 1 – 7 . The remodelling of the host-cell membranes for the formation… read more here.
Keywords: replication machinery; viral replication; microscopy; membrane ... See more keywords
KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008025
Abstract: Kaposi’s sarcoma associated herpesvirus (KSHV), like all herpesviruses maintains lifelong persistence with its host genome in latently infected cells with only a small fraction of cells showing signatures of productive lytic replication. Modulation of cellular… read more here.
Keywords: replication machinery; degradation; kshv; kshv encoded ... See more keywords