Tombusviruses orchestrate the host endomembrane system to create elaborate membranous replication organelles.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2021.03.007
Abstract: Positive-strand RNA viruses depend on intensive manipulation of subcellular organelles and membranes to create unique viral replication organelles (VROs), which represent the sites of robust virus replication. The host endomembrane-based protein-trafficking and vesicle-trafficking pathways are… read more here.
Keywords: system; host endomembrane; host; replication ... See more keywords
A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.05.24.493328
Abstract: As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication. Yet, our understanding of the… read more here.
Keywords: enterovirus replication; replication organelles; replication; host protein ... See more keywords
Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy
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DOI: 10.1128/mbio.00951-19
Abstract: Enteroviruses are causative agents of a range of human diseases. The replication of these viruses within cells relies on specialized membranous structures termed replication organelles (ROs) that form during infection but whose origin remains elusive.… read more here.
Keywords: microscopy; replication; whole cell; replication organelles ... See more keywords
SNAP23 is essential for germination of EV-D68 replication organelles.
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.2139/ssrn.4226394
Abstract: Picornaviruses rearrange host cell membranes to facilitate their own replication. Here we investigate the Qbc SNARE, SNAP23, which is found at the plasma membrane and plays roles in exocytosis. We found that knockdown of SNAP23… read more here.
Keywords: replication organelles; replication; snap23 essential; rna replication ... See more keywords