Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory subunit 2
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DOI: 10.1002/ddr.21978
Abstract: Replication protein A 3 (RPA3) is a significant component of replication protein A and has been documented to function as an oncogene in several types of cancers. However, the role and underlying mechanism of RPA3… read more here.
Keywords: cell; mtor signaling; akt mtor; cisplatin sensitivity ... See more keywords
Replication Protein A Utilizes Differential Engagement of Its DNA-Binding Domains to Bind Biologically Relevant ssDNAs in Diverse Binding Modes.
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DOI: 10.1021/acs.biochem.2c00504
Abstract: Replication protein A (RPA) is a ubiquitous ssDNA-binding protein that functions in many DNA processing pathways to maintain genome integrity. Recent studies suggest that RPA forms a highly dynamic complex with ssDNA that can engage… read more here.
Keywords: dna; biologically relevant; rpa; binding modes ... See more keywords
APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1201
Abstract: Abstract Many APOBEC cytidine deaminase members are known to induce ‘off-target’ cytidine deaminations in 5′TC motifs in genomic DNA that contribute to cancer evolution. In this report, we characterized APOBEC1, which is a possible cancer… read more here.
Keywords: replication protein; cytosine deaminase; apobec1 cytosine; dna ... See more keywords
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1121
Abstract: Abstract The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has roles in lipid metabolism by altering mRNA coding, adaptive… read more here.
Keywords: competition dna; single stranded; dna; stranded dna ... See more keywords
DNA-binding mechanism and evolution of replication protein A
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DOI: 10.1101/2022.07.20.500673
Abstract: Here the authors present the structure of Replication Protein A (RPA) in Archaea. The RPA structure from P. abyssi has been determined in presence and absence of DNA, providing insights into the evolution of this… read more here.
Keywords: dna; replication; evolution replication; rpa ... See more keywords
Function and Structural Organization of the Replication Protein of Bamboo mosaic virus
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00522
Abstract: The genus Potexvirus is one of the eight genera belonging to the family Alphaflexiviridae according to the Virus Taxonomy 2015 released by International Committee on Taxonomy of Viruses (www.ictvonline.org/index.asp). Currently, the genus contains 35 known… read more here.
Keywords: replication protein; mosaic virus; virus; bamboo mosaic ... See more keywords
In Vivo Targeting Replication Protein A for Cancer Therapy
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DOI: 10.3389/fonc.2022.826655
Abstract: Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for… read more here.
Keywords: chemical rpa; replication; rpa; cancer ... See more keywords