Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2020.12.022
Abstract: Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that persists as a multicopy episome in proliferating host cells. Episome maintenance is strictly dependent on EBNA1, a sequence-specific DNA-binding protein with no known enzymatic activities. Here,… read more here.
Keywords: replication; replication termination; episome maintenance; dna ... See more keywords
CUL-2LRR-1 and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis
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DOI: 10.1038/ncb3500
Abstract: Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45–MCM–GINS). Using Caenorhabditis elegans early embryos and Xenopus laevis egg extracts, we show that… read more here.
Keywords: replication termination; dna replication; replisome disassembly; cul 2lrr ... See more keywords