DNA replication timing: Biochemical mechanisms and biological significance
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200097
Abstract: The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the… read more here.
Keywords: replication; replication timing; timing biochemical; timing regulated ... See more keywords
Replication Domains: Genome Compartmentalization into Functional Replication Units.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-6955-0_11
Abstract: DNA replication occurs in a defined temporal order during S phase, known as the replication timing programme, which is regulated not only during the cell cycle but also during the process of development and differentiation.… read more here.
Keywords: cell; replication timing; replication domains; replication ... See more keywords
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109722
Abstract: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects higher-order levels of genome architecture is… read more here.
Keywords: replication timing; replication; dna replication; genome organization ... See more keywords
Collective regulation of chromatin modifications predicts replication timing during cell cycle
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109799
Abstract: SUMMARY Replication timing (RT) associates with genome architecture, while having a mixed relationship to histone marks. By profiling replication at high resolution and assessing broad histone marks across the cell cycle at the resolution of… read more here.
Keywords: cell; chromatin; replication timing; histone marks ... See more keywords
Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00433
Abstract: Fluorescence microscopy imaging of specific chromosomal sites is essential for genome architecture research. To enable visualization of endogenous loci in mammalian cells, programmable DNA-binding proteins such as TAL effectors and CRISPR/dCas9 are commonly utilized. In… read more here.
Keywords: imaging method; replication; replication timing; crispr dcas9 ... See more keywords
Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins
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DOI: 10.1038/s41598-019-46229-1
Abstract: DNA replication is initiated at replication origins on chromosomes at their scheduled time during S phase of the cell cycle. Replication timing control is highly conserved among eukaryotes but the underlying mechanisms are not fully… read more here.
Keywords: replication timing; dna replication; telomere dna; internal late ... See more keywords
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac082
Abstract: Cellular proliferation depends on the accurate and timely replication of the genome. Several genetic diseases are caused by mutations in key DNA replication genes; however, it remains unclear whether these genes influence the normal program… read more here.
Keywords: 184 cell; replication; replication timing; dna replication ... See more keywords
Peripheral re-localization of constitutive heterochromatin advances its replication timing and impairs maintenance of silencing marks
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky368
Abstract: Abstract The replication of the genome is a highly organized process, both spatially and temporally. Although a lot is known on the composition of the basic replication machinery, how its activity is regulated is mostly… read more here.
Keywords: replication timing; maintenance; silencing marks; constitutive heterochromatin ... See more keywords
Mammalian DNA Replication Timing.
Sign Up to like & getrecommendations! Published in 2021 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a040162
Abstract: Immediately following the discovery of the structure of DNA and the semi-conservative replication of the parental DNA sequence into two new DNA strands, it became apparent that DNA replication is organized in a temporal and… read more here.
Keywords: dna replication; replication; replication timing; mammalian dna ... See more keywords
Replication timing networks reveal a link between transcription regulatory circuits and replication timing control.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.247049.118
Abstract: DNA replication occurs in a defined temporal order known as the replication timing (RT) program and is regulated during development, coordinated with 3D genome organization and transcriptional activity. However, transcription and RT are not sufficiently… read more here.
Keywords: transcription; control; replication timing; regulatory networks ... See more keywords
Replication timing maintains the global epigenetic state in human cells
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.aba5545
Abstract: Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing,… read more here.
Keywords: genome architecture; replication timing; replication; epigenetic state ... See more keywords