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   Articles with "replication timing" as a keyword



DNA replication timing: Biochemical mechanisms and biological significance

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recommendations! Published in 2022 at "BioEssays"

DOI: 10.1002/bies.202200097

Abstract: The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle—How is replication timing regulated?—and from an evolutionary one—Why is replication timing regulated? Recent work has provided significant insight into the… read more here.

Keywords: replication; replication timing; timing biochemical; timing regulated ... See more keywords

Replication Domains: Genome Compartmentalization into Functional Replication Units.

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recommendations! Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-981-10-6955-0_11

Abstract: DNA replication occurs in a defined temporal order during S phase, known as the replication timing programme, which is regulated not only during the cell cycle but also during the process of development and differentiation.… read more here.

Keywords: cell; replication timing; replication domains; replication ... See more keywords
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DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109722

Abstract: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects higher-order levels of genome architecture is… read more here.

Keywords: replication timing; replication; dna replication; genome organization ... See more keywords
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Collective regulation of chromatin modifications predicts replication timing during cell cycle

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109799

Abstract: SUMMARY Replication timing (RT) associates with genome architecture, while having a mixed relationship to histone marks. By profiling replication at high resolution and assessing broad histone marks across the cell cycle at the resolution of… read more here.

Keywords: cell; chromatin; replication timing; histone marks ... See more keywords

Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus.

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recommendations! Published in 2023 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.2c00433

Abstract: Fluorescence microscopy imaging of specific chromosomal sites is essential for genome architecture research. To enable visualization of endogenous loci in mammalian cells, programmable DNA-binding proteins such as TAL effectors and CRISPR/dCas9 are commonly utilized. In… read more here.

Keywords: imaging method; replication; replication timing; crispr dcas9 ... See more keywords

Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-52544-7

Abstract: Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain understudied in aneuploid tumors. We developed… read more here.

Keywords: replication; replication timing; single cell; cell ... See more keywords

Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-46229-1

Abstract: DNA replication is initiated at replication origins on chromosomes at their scheduled time during S phase of the cell cycle. Replication timing control is highly conserved among eukaryotes but the underlying mechanisms are not fully… read more here.

Keywords: replication timing; dna replication; telomere dna; internal late ... See more keywords

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryos

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08694-5

Abstract: Analysis of a cell’s replication timing (RT) provides insight into how genes replicate, early or late, during the S-phase of the cell cycle. RT is cell-type specific, inheritable, and has been correlated to gene expression… read more here.

Keywords: replication timing; single cell; gene expression; cell ... See more keywords

Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast

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recommendations! Published in 2025 at "Nucleus"

DOI: 10.1080/19491034.2025.2476935

Abstract: ABSTRACT Replication timing during S-phase impacts mutation rates in yeast and human cancers; however, the exact mechanism involved remains unclear. Here, we analyze the impact of replication timing on UV mutagenesis in Saccharomyces cerevisiae. Our… read more here.

Keywords: replication; replication timing; mutagenesis; repair ... See more keywords

Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.

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recommendations! Published in 2022 at "Human molecular genetics"

DOI: 10.1093/hmg/ddac082

Abstract: Cellular proliferation depends on the accurate and timely replication of the genome. Several genetic diseases are caused by mutations in key DNA replication genes; however, it remains unclear whether these genes influence the normal program… read more here.

Keywords: 184 cell; replication; replication timing; dna replication ... See more keywords

Peripheral re-localization of constitutive heterochromatin advances its replication timing and impairs maintenance of silencing marks

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky368

Abstract: Abstract The replication of the genome is a highly organized process, both spatially and temporally. Although a lot is known on the composition of the basic replication machinery, how its activity is regulated is mostly… read more here.

Keywords: replication timing; maintenance; silencing marks; constitutive heterochromatin ... See more keywords