Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.11.016
Abstract: Transcription of SARS-CoV-2 mRNA requires sequential reactions facilitated by the replication and transcription complex (RTC). Here, we present a structural snapshot of SARS-CoV-2 RTC as it transition towards cap structure synthesis. We determine the atomic… read more here.
Keywords: cap; structure; replication transcription; sars cov ... See more keywords
Chromatin conformation regulates the coordination between DNA replication and transcription
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DOI: 10.1038/s41467-018-03539-8
Abstract: Chromatin is the template for the basic processes of replication and transcription, making the maintenance of chromosomal integrity critical for cell viability. To elucidate how dividing cells respond to alterations in chromatin structure, here we… read more here.
Keywords: chromatin structure; chromatin; dna replication; replication transcription ... See more keywords
Architecture of a SARS-CoV-2 mini replication and transcription complex
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DOI: 10.1038/s41467-020-19770-1
Abstract: Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic structure of a SARS-CoV-2 mini RTC, assembled by viral… read more here.
Keywords: replication transcription; sars cov; rna; transcription complex ... See more keywords
Tobacco-specific nitrosamine 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA) causes DNA damage and impaired replication/transcription in human lung cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267839
Abstract: Thirdhand smoke (THS) is a newly described health hazard composed of toxicants, mutagens and carcinogens, including nicotine-derived tobacco specific nitrosamines (TSNAs), one of which is 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal (NNA). Although TSNAs are generally potent carcinogens, the risk… read more here.
Keywords: replication transcription; transcription; exposure; dna damage ... See more keywords
The mechanism of genome replication and transcription in bunyaviruses
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DOI: 10.1371/journal.ppat.1011060
Abstract: Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority diseases requiring urgent development of medical countermeasures highlighting their high… read more here.
Keywords: genome replication; replication; replication transcription; mechanism genome ... See more keywords
RECQL5 at the Intersection of Replication and Transcription
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DOI: 10.3389/fcell.2020.00324
Abstract: Maintenance of genome stability is essential to prevent the accumulation of DNA mutations that can initiate oncogenesis and facilitate tumor progression. Studies of DNA repair genes have revealed a highly dynamic and redundant network of… read more here.
Keywords: genome stability; transcription; dna repair; replication transcription ... See more keywords
Bacillus subtilis PcrA Couples DNA Replication, Transcription, Recombination and Segregation
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DOI: 10.3389/fmolb.2020.00140
Abstract: Bacillus subtilis PcrA abrogates replication-transcription conflicts in vivo and disrupts RecA nucleoprotein filaments in vitro. Inactivation of pcrA is lethal. We show that PcrA depletion lethality is suppressed by recJ (involved in end resection), recA… read more here.
Keywords: replication transcription; transcription; bacillus subtilis; subtilis pcra ... See more keywords
Structure Prediction and Analysis of Hepatitis E Virus Non-Structural Proteins from the Replication and Transcription Machinery by AlphaFold2
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DOI: 10.3390/v14071537
Abstract: Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in humans globally. Considered for a long while a public health issue only in developing countries, the HEV infection is now a global… read more here.
Keywords: structure; replication transcription; hepatitis virus; hepatitis ... See more keywords