Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.06.003
Abstract: The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). MMR defects are well known to be… read more here.
Keywords: human cancers; dna; dna polymerase; polymerase ... See more keywords
Processive Activity of Replicative DNA Polymerases in the Replisome of Live Eukaryotic Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.014
Abstract: DNA replication is carried out by a multi-protein machine called the replisome. In Saccharomyces cerevisiae, the replisome is composed of over 30 different proteins arranged into multiple subassemblies, each performing distinct activities. Synchrony of these… read more here.
Keywords: dna; dna polymerases; activity replicative; processive activity ... See more keywords
The combined DNA and RNA synthetic capabilities of archaeal DNA primase facilitate primer hand-off to the replicative DNA polymerase
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28093-2
Abstract: Replicative DNA polymerases cannot initiate DNA synthesis de novo and rely on dedicated RNA polymerases, primases, to generate a short primer. This primer is then extended by the DNA polymerase. In diverse archaeal species, the… read more here.
Keywords: dna; dna polymerase; primer; primase ... See more keywords
Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab801
Abstract: Abstract Ribonucleoside triphosphate (rNTP) incorporation in DNA by DNA polymerases is a frequent phenomenon that results in DNA structural change and genome instability. However, it is unclear whether the rNTP incorporation into DNA follows any… read more here.
Keywords: autonomously replicating; dna; rntp incorporation; dna polymerases ... See more keywords
Genome Instability Induced by Low Levels of Replicative DNA Polymerases in Yeast
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes9110539
Abstract: Most cells of solid tumors have very high levels of genome instability of several different types, including deletions, duplications, translocations, and aneuploidy. Much of this instability appears induced by DNA replication stress. As a model… read more here.
Keywords: instability; replicative dna; dna; dna polymerases ... See more keywords
Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098078
Abstract: Replicative DNA polymerases, such as DNA polymerase α-primase, δ and ε, are multi-subunit complexes that are responsible for the bulk of nuclear DNA replication during the S phase. Over the last decade, extensive genome-wide association… read more here.
Keywords: dna; dna polymerase; human diseases; polymerase genes ... See more keywords