Expansion of adipose tissue‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescence
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3267
Abstract: Multipotent mesenchymal stromal cells are considered as a perspective tool in cell therapy and regenerative medicine. Unfortunately, autologous cell therapy does not always provide positive outcomes in elder donors, perhaps as a result of the… read more here.
Keywords: replicative senescence; stromal cells; senescence; adipose tissue ... See more keywords
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05140-8
Abstract: Human diploid fibroblasts (HDFs) cultured in vitro have limited capacity to proliferate after population doubling is repeated several times, and they enter into a state known as replicative senescence or cellular senescence. This study aimed… read more here.
Keywords: senescent hdfs; replicative senescence; senescence associated; senescence ... See more keywords
Replicative senescence of human dermal fibroblasts affects structural and functional aspects of the Golgi apparatus
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.13886
Abstract: It is well recognized that the world population is ageing rapidly. Therefore, it is important to understand ageing processes at the cellular and molecular levels to predict the onset of age‐related diseases and prevent them.… read more here.
Keywords: human dermal; replicative senescence; golgi; golgi apparatus ... See more keywords
Tocotrienol-Rich Fraction Ameliorates Antioxidant Defense Mechanisms and Improves Replicative Senescence-Associated Oxidative Stress in Human Myoblasts
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/3868305
Abstract: During aging, oxidative stress affects the normal function of satellite cells, with consequent regeneration defects that lead to sarcopenia. This study aimed to evaluate tocotrienol-rich fraction (TRF) modulation in reestablishing the oxidative status of myoblasts… read more here.
Keywords: replicative senescence; oxidative stress; senescence; rich fraction ... See more keywords
Exogenous Hydrogen Sulfide Activates PI3K/Akt/eNOS Pathway to Improve Replicative Senescence in Human Umbilical Vein Endothelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cardiology Research and Practice"
DOI: 10.1155/2023/7296874
Abstract: Background Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling plays an important role in… read more here.
Keywords: pi3k akt; akt enos; endothelial cells; senescence ... See more keywords
Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204784
Abstract: Background aims Delaying replicative senescence and extending lifespan of human mesenchymal stromal cells (MSCs) may enhance their potential for tissue engineering and cell based therapies. Accumulating evidence suggests that inhibitors of the mTOR signaling pathway,… read more here.
Keywords: mesenchymal stromal; replicative senescence; senescence; delaying replicative ... See more keywords
Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302391
Abstract: Mecl/ATR and Tell/ATM trigger replicative senescence when telomeres become critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still unclear. Menin et al. studied the functions of Saccharomyces cerevisiae Tel1 in… read more here.
Keywords: replicative senescence; tel1; absence telomerase; senescence ... See more keywords
Fast assay to predict multipotent mesenchymal stromal cell replicative senescence dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "BioTechniques"
DOI: 10.2144/btn-2021-0087
Abstract: The major obstacle to the application of mesenchymal stromal cells (MSCs) in regenerative medicine is the expansion of the donor-derived cells in vitro to obtain high cell numbers in the shortest possible time. However, MSCs gradually undergo replicative… read more here.
Keywords: cell; mesenchymal stromal; fast assay; senescence ... See more keywords
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s374951
Abstract: Background In most cell types, replicative senescence (RS) is supposed to be a principle causative factor for aging. Atrial fibrosis, pathologically characterized by proliferation of atrial fibroblasts (AFs) and excessive accumulation of extracellular matrix proteins,… read more here.
Keywords: ezh2 inhibits; promoter regions; replicative senescence; atrial fibroblasts ... See more keywords
CHIR99021 Augmented the Function of Late Endothelial Progenitor Cells by Preventing Replicative Senescence
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094796
Abstract: Endothelial progenitor cells (EPCs) are specialized cells in circulating blood, well known for their ability to form new vascular structures. Aging and various ailments such as diabetes, atherosclerosis and cardiovascular disease make EPCs vulnerable to… read more here.
Keywords: progenitor cells; replicative senescence; senescence; endothelial progenitor ... See more keywords
Senescence-associated secretory phenotypes in rat-derived dedifferentiated fat cells with replicative senescence.
Sign Up to like & getrecommendations! Published in 2023 at "Dental materials journal"
DOI: 10.4012/dmj.2022-242
Abstract: Senescence-associated secretory phenotype (SASPs) secreted from senescent cells often cause the deleterious damages to the surrounding tissues. Although dedifferentiated fat (DFAT) cells prepared are considered a promising cell source for regenerative therapies, SASPs from DFAT… read more here.
Keywords: dfat cells; dedifferentiated fat; associated secretory; senescence ... See more keywords