Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops
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DOI: 10.1093/nar/gkac296
Abstract: Abstract Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand breaks in the… read more here.
Keywords: strand bias; replicative strand; preference; deaminase ... See more keywords