Abstract A32: Exploring the interplay between nucleotide excision repair and DNA replicative stress
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DOI: 10.1158/1557-3125.dnarepair16-a32
Abstract: Ultraviolet (UV) light causes highly genotoxic DNA lesions that are removed by nucleotide excision repair (NER), and NER is critical for preventing UV-associated skin cancers. UV-induced DNA lesions block the progression of DNA polymerases, leading… read more here.
Keywords: replicative stress; excision repair; nucleotide excision; ner ... See more keywords
A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response
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DOI: 10.1371/journal.pbio.3001543
Abstract: Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bound… read more here.
Keywords: dna; stress response; induced replicative; replicative stress ... See more keywords
Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration
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DOI: 10.3390/cancers13071656
Abstract: Simple Summary Triple-negative breast cancer (TNBC) is a subtype of invasive breast cancer with an aggressive phenotype that has decreased survival compared with other types of breast cancers, due in part to the lack of… read more here.
Keywords: replicative stress; dna repair; kinase; breast ... See more keywords