Construction and characterization of two SARS‐CoV‐2 minigenome replicon systems
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27650
Abstract: The ongoing COVID‐19 pandemic severely impacts global public health and economies. To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virology and antiviral discovery, a noninfectious viral replicon system operating under biosafety level… read more here.
Keywords: cov2 rep; replicon systems; replicon; sars cov ... See more keywords
Development of a stable Japanese encephalitis virus replicon cell line for antiviral screening
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3508-9
Abstract: Japanese encephalitis virus (JEV), an important pathogen in Eastern and Southern Asia and the Pacific, has spread to Australia and other territories in recent years. Although the vaccine for JEV has been used in some… read more here.
Keywords: cell line; jev; replicon; cell ... See more keywords
Establishment of robust HCV genotype 4d, 5a, and 6a replicon systems.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.11.003
Abstract: Hepatitis C Virus (HCV) is a diverse human pathogen which displays ~15% divergence at the subtype level. To facilitate development of antivirals with pan-genotype activity, we developed the first genotype 4d subgenomic replicon, as well… read more here.
Keywords: inhibitor; genotype replicon; establishment robust; hcv ... See more keywords
West Nile virus infectious replicon particles generated using a packaging-restricted cell line is a safe reporter system
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03670-4
Abstract: West Nile virus (WNV) is a neurotropic pathogen which causes zoonotic disease in humans. Recently, there have been an increasing number of infected cases and there are no clinically approved vaccines or effective drugs to… read more here.
Keywords: replicon particles; replicon; cell line; virus ... See more keywords
Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111075118
Abstract: Significance Coronaviruses (CoVs) have the largest genome among RNA viruses and a proofreading exoribonuclease (nsp14) responsible for high-fidelity RNA synthesis. These properties make CoVs very attractive for the establishment of vaccine platforms or viral vectors… read more here.
Keywords: replicon; propagation defective; mers cov; vaccine ... See more keywords
Antiviral Candidates for Treating Hepatitis E Virus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00003-19
Abstract: Globally, hepatitis E virus (HEV) causes significant morbidity and mortality each year. Despite this burden, there are no specific antivirals available to treat HEV patients, and the only licensed vaccine is not available outside China.… read more here.
Keywords: hev; infection; hepatitis virus; hev infection ... See more keywords
IncFIB-4.1 and IncFIB-4.2 Single-Replicon Plasmids: Small Backbones with Large Accessory Regions
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DOI: 10.2147/idr.s332949
Abstract: Purpose To establish a typing scheme for IncFIB replicon and to dissect genomic features of IncFIB-4.1/4.2 single-replicon plasmids. Methods A total of 146 representative fully sequenced IncFIB-replicon-containing plasmids were selected to construct a phylogenetic tree… read more here.
Keywords: replicon; single replicon; incfib single; resistance ... See more keywords
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.622385
Abstract: Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever virus (CSFV) targets monocytes and… read more here.
Keywords: immune; reprna; humoral cellular; influenza virus ... See more keywords
High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles
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DOI: 10.3390/v14020346
Abstract: Flavivirus outbreaks require fast and reliable diagnostics that can be easily adapted to newly emerging and re-emerging flaviviruses. Due to the serological cross-reactivity among flavivirus antibodies, neutralization tests (NT) are considered the gold standard for… read more here.
Keywords: replicon; reporter; replicon particles; high throughput ... See more keywords
A highly pathogenic porcine reproductive and respiratory syndrome virus candidate vaccine based on Japanese encephalitis virus replicon system
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DOI: 10.7717/peerj.3514
Abstract: In the swine industry, porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease which causes heavy economic losses worldwide. Effective prevention and disease control is an important issue. In this study, we described… read more here.
Keywords: jev dna; japanese encephalitis; vaccine; replicon ... See more keywords