CUL-2LRR-1 and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature cell biology"
DOI: 10.1038/ncb3500
Abstract: Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45–MCM–GINS). Using Caenorhabditis elegans early embryos and Xenopus laevis egg extracts, we show that… read more here.
Keywords: replication termination; dna replication; replisome disassembly; cul 2lrr ... See more keywords
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
Sign Up to like & getrecommendations! Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201900390
Abstract: Analysis of the mitotic replisome disassembly pathway in X. laevis egg extract shows that any replisomes retained on chromatin past S-phase are unloaded through formation of K6- and K63-linked ubiquitin chains on Mcm7 by TRAIP… read more here.
Keywords: replisome; traip ubiquitin; ubiquitin ligase; mitotic replisome ... See more keywords
The Fate of Two Unstoppable Trains After Arriving Destination: Replisome Disassembly During DNA Replication Termination
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.658003
Abstract: In eukaryotes, the perfect duplication of the chromosomes is executed by a dynamic molecular machine called the replisome. As a key step to finishing DNA replication, replisome disassembly is triggered by ubiquitylation of the MCM7… read more here.
Keywords: replisome; two unstoppable; fate two; dna replication ... See more keywords