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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11355-1
Abstract: Some cardiovascular and non-cardiovascular drugs frequently cause excessive prolongation of the cardiac action potential (AP) and lead to the development of early afterdepolarisations (EADs), which trigger lethal ventricular arrhythmias. Combining computer simulations in APs with…
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Keywords:
repolarisation reserve;
reserve attenuation;
multi stable;
repolarisation ... See more keywords
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Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1470621
Abstract: ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of sudden death. Implantable cardioverter defibrillators (ICDs) are a first line protection against…
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Keywords:
short syndrome;
therapeutic targets;
repolarisation;
channel ... See more keywords
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Published in 2021 at "Circulation. Genomic and precision medicine"
DOI: 10.1161/circgen.120.003231
Abstract: Background - Electrocardiographic (ECG) markers of ventricular depolarisation and repolarisation are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT…
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Keywords:
mendelian randomization;
repolarisation;
serum calcium;
markers ventricular ... See more keywords
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Published in 2017 at "Cardiovascular Journal of Africa"
DOI: 10.5830/cvja-2016-074
Abstract: Summary Background: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have…
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Keywords:
familial mediterranean;
myocardial repolarisation;
repolarisation;
repolarisation parameters ... See more keywords
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Published in 2017 at "Cardiovascular Journal of Africa"
DOI: 10.5830/cvja-2016-088
Abstract: Summary Early repolarisation is a common electrocardiographic (ECG) finding characterised by J-point and ST segment elevation ≥ 0.1 mV in two or more adjacent leads. The ECG pattern of early repolarisation is relatively common in…
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Keywords:
chest pain;
early repolarisation;
repolarisation;
adolescent boy ... See more keywords