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   Articles with "repopulating cells" as a keyword



Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2016.12.122

Abstract: Tumor-repopulating cells (TRCs) are a tumorigenic sub-population of cancer cells that drives tumorigenesis. We have recently reported that soft fibrin matrices maintain TRC growth by promoting histone 3 lysine 9 (H3K9) demethylation and Sox2 expression… read more here.

Keywords: tumor repopulating; repopulating cells; fibrin matrices; h3k9 methylation ... See more keywords

Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.

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recommendations! Published in 2018 at "Cancer cell"

DOI: 10.1016/j.ccell.2018.02.005

Abstract: Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show that tumor-repopulating cells (TRCs) drive PD-1 upregulation in CD8+ T cells through a transcellular… read more here.

Keywords: kynurenine; tumor repopulating; repopulating cells; cd8 cells ... See more keywords

Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

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recommendations! Published in 2024 at "Nature Chemical Biology"

DOI: 10.1038/s41589-024-01612-6

Abstract: Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with stem-cell-like cancer cell characteristics resist chemotherapy… read more here.

Keywords: tumor repopulating; repopulating cells; ferroptosis; pck2 ... See more keywords

Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/0008-5472.can-20-2569

Abstract: Tumor-repopulating cells evade CD8+ cytolytic T-cell killing through a mechanical softness mechanism, underlying the impediment of perforin pore formation at the immune synapse site. Biomechanics is a fundamental feature of a cell. However, the manner… read more here.

Keywords: tumor repopulating; softness; tumor; cell ... See more keywords