BMI influences CD20 kinetics in multiple sclerosis patients treated with ocrelizumab.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102186
Abstract: OBJECTIVES Ocrelizumab (OCR) is a humanized monoclonal antibody targeting CD20 antigen exposed on B cells surface. Kinetic of B-cells repopulation after depletion therapy shows high intra and inter-individual variability. The aim of this study was… read more here.
Keywords: sclerosis; treatment; repopulation; multiple sclerosis ... See more keywords
Clinical-scale expansion of CD34+ cord blood cells amplifies committed progenitors and rapid scid repopulation cells.
Sign Up to like & getrecommendations! Published in 2017 at "New biotechnology"
DOI: 10.1016/j.nbt.2016.10.011
Abstract: Umbilical cord blood (UCB) transplantation is associated with long periods of aplastic anaemia. This undesirable situation is due to the low cell dose available per unit of UCB and the immaturity of its progenitors. To… read more here.
Keywords: cd34; cord blood; repopulation; expansion cd34 ... See more keywords
Platelet-activating factor (PAF) receptor as a promising target for cancer cell repopulation after radiotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Oncogenesis"
DOI: 10.1038/oncsis.2016.90
Abstract: A major drawback of radiotherapy is the accelerated growth of the surviving tumor cells. Radiotherapy generates a variety of lipids that bind to the receptor for platelet-activating factor, expressed by cells in the tumor microenvironment.… read more here.
Keywords: platelet activating; radiotherapy; repopulation; receptor ... See more keywords
In-vivo Comparison of 18F-FLT uptake, CT Number, Tumor Volume in Evaluation of Repopulation during Radiotherapy for Lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46000
Abstract: Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume… read more here.
Keywords: tumor volume; repopulation; flt uptake; 18f flt ... See more keywords
High-content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.11.025
Abstract: BACKGROUND & AIMS Liver regeneration is impaired in mice with hepatocyte-specific deficiencies in microRNA (miRNA) processing, but it is not clear which miRNAs regulate this process. We developed a high-throughput screen to identify miRNAs that… read more here.
Keywords: high content; required liver; liver repopulation; repopulation ... See more keywords
P207 A proposal for individually tailored rituximab treatment based on clinical and B-cell biomarkers for remission maintenance in ANCA associated vasculitis
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab247.202
Abstract: Background/Aims Time-to-relapse after rituximab for ANCA vasculitis is variable and optimal retreatment strategy is unclear. We previously showed that repopulation of naïve B-cells at 6 months predicts sustained response. Our objective was to evaluate clinical… read more here.
Keywords: repopulation; relapse; mva; cell ... See more keywords
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aap8492
Abstract: Chemokine signaling via CX3CL1-CX3CR1 helps regulate homeostasis in the population of microglia in the adult mouse retina. Microglia have been discovered to undergo repopulation following ablation. However, the functionality of repopulated microglia and the mechanisms… read more here.
Keywords: organization function; repopulation; cx3cl1 cx3cr1; cx3cr1 ... See more keywords
Time course of lymphocyte repopulation after dimethyl fumarate-induced grade 3 lymphopenia: contribution of patient age
Sign Up to like & getrecommendations! Published in 2019 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/1756286419843450
Abstract: Background: Dimethyl fumarate (DMF) is licensed for treatment of relapsing–remitting multiple sclerosis (RRMS). DMF can induce lymphopenia, which is assumed to increase the risk for opportunistic infections like progressive multifocal leukoencephalopathy. Our goal for this… read more here.
Keywords: time course; course lymphocyte; grade lymphopenia; repopulation ... See more keywords
Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01847-9
Abstract: Objective To characterize long-term repopulation of peripheral immune cells following alemtuzumab-induced lymphopenia in relapsing-remitting MS (RRMS), with a focus on regulatory cell types, and to explore associations with clinical outcome measures. Methods The project was… read more here.
Keywords: relapsing remitting; cells following; treatment; following alemtuzumab ... See more keywords
Reoxygenation and Repopulation of Tumor Cells after Ablative Hypofractionated Radiotherapy (SBRT and SRS) in Murine Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Radiation Research"
DOI: 10.1667/rr15346.1
Abstract: In this work, we investigated the change in tumor microenvironment caused by semi-ablative high-dose irradiation and its implication on tumor cell survival, reoxygenation of hypoxic cells and repopulation in FSaII tumors grown subcutaneously in the… read more here.
Keywords: hypoxic cells; repopulation; tumor cells; cell ... See more keywords
Short-Term Colony-Stimulating Factor 1 Receptor Inhibition–Induced Repopulation After Stroke Assessed by Longitudinal 18F-DPA-714 PET Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.121.263004
Abstract: Visual Abstract Studies on colony-stimulating factor 1 receptor (CSF-1R) inhibition–induced microglia depletion indicated that inhibitor withdrawal allowed the renewal of the microglia compartment via repopulation and resolved the inflammatory imbalance. Therefore, we investigated for the… read more here.
Keywords: dpa 714; inhibition; repopulation; 18f dpa ... See more keywords