The mito::mKate2 mouse: A far‐red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo
Sign Up to like & getrecommendations! Published in 2018 at "genesis"
DOI: 10.1002/dvg.23087
Abstract: Mitochondria are incredibly dynamic organelles that undergo continuous fission and fusion events to control morphology, which profoundly impacts cell physiology including cell cycle progression. This is highlighted by the fact that most major human neurodegenerative… read more here.
Keywords: mitochondrial dynamics; reporter mouse; mouse; mito mkate2 ... See more keywords
Generation of Pecam1 endothelial specific dual reporter mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Genesis"
DOI: 10.1002/dvg.23384
Abstract: Endothelial cells are specialized epithelium lining the interior surface of vessels and play fundamental roles in angiogenesis, vascular permeability, and immune response. To identify endothelial cells in vivo, we constructed a Pecam1nlacZ-H2B-GFP/+ knock-in mouse model… read more here.
Keywords: reporter mouse; gfp; endothelial cells; mouse model ... See more keywords
Study of IgE-Producing B Cells Using the Verigem Fluorescent Reporter Mouse.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7896-0_19
Abstract: Immunoglobulin E (IgE) is the least abundant antibody isotype in mammalians, yet it plays a critical role in allergy and asthma. IgE-producing (IgE+) B cells are rare and difficult to detect, which have hindered progress… read more here.
Keywords: reporter mouse; ige producing; ige; study ige ... See more keywords
The Genetic Basis of Reporter Mouse Strains.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6064-8_21
Abstract: Genetically engineered mouse (GEM) models have been revolutionizing the biomedical studies on deciphering the physiological roles of genes in vivo. In addition to deactivating a gene in mice, diverse strategies have been created to monitor… read more here.
Keywords: reporter mouse; genetic basis; mouse strains; basis reporter ... See more keywords
Abstract 2393: Characterization and validation of a Smad3/TGFb pathway reporter mouse for analysis of TGFβ signaling in normal homeostasis and cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2393
Abstract: TGFβs play a central regulatory role in maintaining homeostasis in the adult animal, and dysregulation of TGFβ signaling occurs in many cancers. Consequently, TGFβ pathway antagonists are now in early phase clinical oncology trials, but… read more here.
Keywords: reporter; tgf; cancer; characterization ... See more keywords
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.32417
Abstract: Calcium is an essential cellular messenger that regulates numerous functions in living organisms. Here, we describe development and characterization of ‘Salsa6f’, a fusion of GCaMP6f and tdTomato optimized for cell tracking while monitoring cytosolic Ca2+,… read more here.
Keywords: reporter mouse; gcamp6f; tdtomato; salsa6f ... See more keywords