Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH1-24 Depot and Methylprednisolone in Healthy Subjects.
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DOI: 10.1002/cpdd.1020
Abstract: Repository corticotropin injection (RCI; Acthar Gel) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1, single-center, open-label, randomized parallel study directly compared the pharmacokinetics and pharmacodynamics… read more here.
Keywords: repository corticotropin; rci; synthetic acth1; acth1 depot ... See more keywords
Repository corticotropin for Chronic Pulmonary Sarcoidosis
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DOI: 10.1007/s00408-017-9994-4
Abstract: PurposeThe dose of repository corticotropin (RCI) and need for a loading dose in sarcoidosis patients receiving chronic corticosteroids are unclear. We performed a single-blind prospective study, comparing two doses of RCI in sarcoidosis.MethodsChronic pulmonary sarcoidosis… read more here.
Keywords: repository corticotropin; corticotropin; unit rci; sarcoidosis ... See more keywords
Consequences of Insurance Denials Among U.S. Patients Prescribed Repository Corticotropin Injection for Acute Exacerbations of Multiple Sclerosis
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DOI: 10.1007/s40120-020-00219-y
Abstract: Repository corticotropin injection (RCI; Acthar® Gel) is indicated for the treatment of acute exacerbations of multiple sclerosis (MS) in adults. Despite the well-documented clinical and economic benefits of RCI, many patients are denied use of… read more here.
Keywords: repository corticotropin; acute exacerbations; rci; corticotropin injection ... See more keywords
Outcomes of Repository Corticotropin Gel for Ocular Sarcoidosis.
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DOI: 10.1080/09273948.2021.1884887
Abstract: Purpose: To evaluate the utility and side effect profile of subcutaneous repository corticotropin gel (RCI) in ocular sarcoidosis.Methods: Retrospective chart review.Results: Among six identified patients on RCI therapy, 4 had uveitis, one had optic neuritis… read more here.
Keywords: repository corticotropin; rci therapy; inflammation; corticotropin gel ... See more keywords
Repository Corticotropin Injection as an Alternative Treatment for Refractory Ocular Mucous Membrane Pemphigoid
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DOI: 10.1097/ico.0000000000002771
Abstract: Purpose: The purpose of this study was to report the clinical course and outcome of patients with refractory ocular mucous membrane pemphigoid (MMP) treated by repository corticotropin injection (RCI). Methods: Patients with biopsy-proven ocular MMP… read more here.
Keywords: ocular mucous; treatment; repository corticotropin; refractory ocular ... See more keywords