ZNF410 represses fetal globin by singular control of CHD4.
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DOI: 10.1038/s41588-021-00843-w
Abstract: Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR screening, we identify zinc-finger protein (ZNF) 410 as an HbF repressor. ZNF410 does not bind… read more here.
Keywords: chd4; fetal globin; represses fetal; globin singular ... See more keywords