How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14409
Abstract: Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid receptor (GR), which regulates transcription of distinct gene networks in… read more here.
Keywords: mechanisms inflammatory; tame genes; genes mechanisms; repression ... See more keywords
CRISPRi repression of nonhomologous end‐joining for enhanced genome engineering via homologous recombination in Yarrowia lipolytica
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26404
Abstract: In many organisms of biotechnological importance precise genome editing is limited by inherently low homologous recombination (HR) efficiencies. A number of strategies exist to increase the effectiveness of this native DNA repair pathway; however, most… read more here.
Keywords: homologous recombination; repression; nonhomologous end; crispri ... See more keywords
Medium composition overturns the widely accepted sulfate-dependent repression of desulfurization phenotype in Rhodococcus qingshengii IGTS8.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28436
Abstract: Microbial desulfurization has been extensively studied as a promising alternative to the widely applied chemical desulfurization process. Sulfur removal from petroleum and its products becomes essential, as the environmental regulations become increasingly stringent. Rhodococcus qingshengii… read more here.
Keywords: repression; desulfurization; medium; igts8 ... See more keywords
Reversing epigenetic repression of transposable elements for improving tumor immunogenicity
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DOI: 10.1002/cac2.12261
Abstract: In a recent study published in Nature, Zhang et al. [1] revealed a new epigenetic mechanism for restraining tumor intrinsic immunogenicity: Lysine demethylase 5B (KDM5B) recruits SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) to… read more here.
Keywords: transposable elements; repression; immunogenicity; reversing epigenetic ... See more keywords
One-two punch mechanism of gene repression: a fresh perspective on gene regulation
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0793-5
Abstract: Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another. It is well established that transcription factor cascades coordinate the timely activation of gene expression… read more here.
Keywords: gene repression; mechanism; repression; gene ... See more keywords
Transient responses of Wickerhamia sp. yeast continuous cultures to qualitative changes in carbon source supply: induction and catabolite repression of α-amylase synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Microbiology"
DOI: 10.1007/s13213-018-1369-4
Abstract: The purpose of this study was to evaluate the inductive effect of starch and maltose, and the repressive/inhibitory effect of glucose, on amy-1 gene expression and α-amylase production by Wickerhamia sp., using continuous culture under… read more here.
Keywords: amylase synthesis; amylase; repression; transient ... See more keywords
Forced FOG1 expression in erythroleukemia cells: Induction of erythroid genes and repression of myelo-lymphoid transcription factor PU.1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.068
Abstract: The transcription factor GATA-1-interacting protein Friend of GATA-1 (FOG1) is essential for proper transcriptional activation and repression of GATA-1 target genes; yet, the mechanisms by which FOG1 exerts its activating and repressing functions remain unknown.… read more here.
Keywords: forced fog1; gata; fog1; repression ... See more keywords
Positive feedback exists and drives the glucose-mediated repression in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.01.017
Abstract: The expression of the lac operon of E. coli is subject to positive feedback during growth in the presence of gratuitous inducers, but its existence in the presence of lactose remains controversial. The key question… read more here.
Keywords: induction; feedback; presence; repression ... See more keywords
Generation of Single-Cell Transcript Variability by Repression
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DOI: 10.1016/j.cub.2017.05.028
Abstract: Summary Gene expression levels vary greatly within similar cells, even within clonal cell populations [1]. These spontaneous expression differences underlie cell fate diversity in both differentiation and disease [2]. The mechanisms responsible for generating expression… read more here.
Keywords: single cell; transcript variability; variability; repression ... See more keywords
Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.11.018
Abstract: Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 have also been suggested, it has remained unclear whether Ub-dependent and -independent functions… read more here.
Keywords: fate restriction; repression; prc1; repression prc1 ... See more keywords
SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2016.12.015
Abstract: &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐binding protein‐1 (Satb1) restrains… read more here.
Keywords: satb1 expression; repression; expression; cell ... See more keywords