Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx884
Abstract: Abstract Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their… read more here.
Keywords: rif1; chromatin state; promotes repressive; activation ... See more keywords
Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1007120
Abstract: X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated… read more here.
Keywords: nuclear periphery; repressive chromatin; emerin; ezh2 g9a ... See more keywords