Polycomb repressive 2 complex—Molecular mechanisms of function
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3647
Abstract: Numerous molecular processes conduct epigenetic regulation of protein transcription to maintain cell specification. In this review, we discuss molecular mechanisms of the Polycomb group of proteins and its enzymatic role in epigenetics. More specifically, we… read more here.
Keywords: polycomb repressive; complex molecular; repressive complex; molecular mechanisms ... See more keywords
Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.01.009
Abstract: Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on… read more here.
Keywords: complex generates; polycomb repressive; repressive complex; differentiation ... See more keywords
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.03.019
Abstract: The maintenance of gene expression patterns during metazoan development is achieved, in part, by the actions of polycomb repressive complex 2 (PRC2). PRC2 catalyzes mono-, di-, and trimethylation of histone H3 at lysine 27 (H3K27),… read more here.
Keywords: polycomb repressive; prc2; repressive complex; distinct stimulatory ... See more keywords
Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01344
Abstract: The polycomb repressive complex 2 (PRC2) is composed of three core subunits, enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 (SUZ12), along with a number of accessory proteins. It… read more here.
Keywords: polycomb repressive; repressive complex; prc2; cancer ... See more keywords
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01161
Abstract: Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently… read more here.
Keywords: polycomb repressive; methyltransferase; repressive complex; subunit ... See more keywords
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin‐induced acute kidney injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17447
Abstract: Polycomb repressive complex 2 (PRC2) is a multicomponent complex with methyltransferase activity that catalyzes trimethylation of histone H3 at lysine 27 (H3K27me3). Interaction of the epigenetic reader protein EED with EZH2, a catalytic unit of… read more here.
Keywords: repressive complex; acute kidney; kidney; polycomb repressive ... See more keywords
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax2887
Abstract: CATACOMB is a catalytic antagonist PRC2 subunit whose expression is induced upon DNA demethylation. Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4… read more here.
Keywords: methylation; polycomb repressive; repressive complex; prc2 ... See more keywords
H2A ubiquitination is essential for Polycomb Repressive Complex 1-mediated gene regulation in Marchantia polymorpha
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology"
DOI: 10.1186/s13059-021-02476-y
Abstract: Background Polycomb repressive complex 1 (PRC1) and PRC2 are chromatin regulators maintaining transcriptional repression. The deposition of H3 lysine 27 tri-methylation (H3K27me3) by PRC2 is known to be required for transcriptional repression, whereas the contribution… read more here.
Keywords: gene regulation; polycomb repressive; polycomb; repressive complex ... See more keywords
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3000221
Abstract: Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must… read more here.
Keywords: erk1 signalling; polycomb; repressive complex; differentiation ... See more keywords
An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0361
Abstract: Polycomb repressive complex 2 (PRC2) catalyses the repressive epigenetic modification, histone 3 lysine 27 tri-methylation (H3K27me3) and functions as a key epigenetic regulator during embryonic development. PRC2 is known to regulate the development of a… read more here.
Keywords: repressive complex; adult; development; mouse ... See more keywords
Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13133155
Abstract: Simple Summary PRC2 (Polycomb repressive complex 2) is a catalytic multi-subunit complex involved in transcriptional repression through the methylation of lysine 27 at histone 3 (H3K27me1/2/3). Dysregulation of PRC2 has been linked to tumor development… read more here.
Keywords: ezh2 suz12; polycomb repressive; clinical correlations; repressive complex ... See more keywords