The activator/repressor Hap1 binds to the yeast eIF5A‐encoding gene TIF51A to adapt its expression to the mitochondrial functional status
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14366
Abstract: Mitochondrial activity adapts to cellular energetic and metabolic demands; its dysfunction is a hallmark of ageing and many human diseases. The evolutionarily conserved translation elongation factor eIF5A is involved in maintaining mitochondrial function. In humans,… read more here.
Keywords: functional status; repressor; mitochondrial functional; expression ... See more keywords
The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14416
Abstract: DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co‐repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The… read more here.
Keywords: repressor; progesterone; nuclear receptors; dux4 protein ... See more keywords
RNA polymerase efficiently transcribes through DNA‐scaffolded, cooperative bacteriophage repressor complexes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14447
Abstract: DNA can act as a scaffold for the cooperative binding of protein oligomers. For example, the phage 186 CI repressor forms a wheel of seven dimers wrapped in DNA with specific binding sites, while phage… read more here.
Keywords: dna; repressor; transcription; rna polymerase ... See more keywords
Cloning and identification of a new repressor of 3,17β-Hydroxysteroid dehydrogenase of Comamonas testosteroni.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06566-9
Abstract: BACKGROUND 3,17β-hydroxysteroid dehydrogenase (3,17β-HSD) is a key enzyme in the metabolic pathway for steroid compounds catabolism in Comamonas testosteroni. Tetracycline repressor (TetR) family, repressors existing in most microorganisms, may play key roles in regulating the… read more here.
Keywords: hsd; repressor; tetr gene; comamonas testosteroni ... See more keywords
Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.070
Abstract: The epithelial to mesenchymal transition (EMT) is a cell intrinsic program controlling cellular morphological and phenotypic remodeling in a wide range of biological processes. Despite the accumulating evidence, the transcriptional networks regulating EMT still remain… read more here.
Keywords: novel transcriptional; mesenchymal transition; transcriptional repressor; repressor ... See more keywords
SA17 PATERNAL AGE AFFECTS OFFSPRING'S BEHAVIOR POSSIBLY VIA EPIGENETIC MECHANISM RECRUITING A TRANSCRIPTIONAL REPRESSOR REST
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.089
Abstract: Background Paternal age has deleterious effects on the transmission of phenotypes to offspring, including higher prevalence of major psychiatric and neurodevelopmental disorders. Methods Here, we examined transgenerational transmission of selected somatic and cognitive phenotypes in… read more here.
Keywords: rest; repressor; epigenetic mechanism; paternal age ... See more keywords
NF-κB c-Rel Dictates the Inflammatory Threshold by Acting as a Transcriptional Repressor
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100876
Abstract: Summary NF-κB/Rel family of transcription factors plays a central role in initiation and resolution of inflammatory responses. Here, we identified a function of the NF-κB subunit c-Rel as a transcriptional repressor of inflammatory genes. Genetic… read more here.
Keywords: transcriptional repressor; repressor; inflammatory threshold; rel dictates ... See more keywords
SB1 Encoding RING-Like Zinc-Finger Protein Regulates Branch Development as a Transcription Repressor
Sign Up to like & getrecommendations! Published in 2021 at "Rice Science"
DOI: 10.1016/j.rsci.2021.04.004
Abstract: Abstract Inflorescence structure of rice, including the number and length of branches, and the density of the spikelet, can greatly affect the number of grains per panicle, which is one of the key factors in… read more here.
Keywords: ring like; transcription repressor; sb1; repressor ... See more keywords
A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00129
Abstract: Monitoring the aggregation of proteins within the cellular environment is key to investigating the molecular mechanisms underlying the formation of off-pathway protein assemblies associated with the development of disease and testing therapeutic strategies to prevent… read more here.
Keywords: aggregation; repressor; synthetic biology; split ... See more keywords
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1921786117
Abstract: Significance MYC is a transcriptional regulator that controls much of the coding and noncoding transcriptome. It is also an oncoprotein that functions as a driver in numerous human cancers. The mechanism of this oncogenic activity… read more here.
Keywords: repressor; cell proliferation; proliferation; myc driven ... See more keywords
Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab077
Abstract: Abstract Populations of Escherichia coli selected in constant and fluctuating environments containing lactose often adapt by substituting mutations in the lacI repressor that cause constitutive expression of the lac operon. These mutations occur at a… read more here.
Keywords: repressor; lac operon; historical contingency; expression lac ... See more keywords