CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.023
Abstract: Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks and mechanistic changes… read more here.
Keywords: reproductive decline; non autonomously; hedgehog; creb ... See more keywords
Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause.
Sign Up to like & getrecommendations! Published in 2018 at "Obstetrics and gynecology clinics of North America"
DOI: 10.1016/j.ogc.2018.07.011
Abstract: This article reviews the role of endogenous estrogen in neural and cognitive processing, followed by an examination of longitudinal cognitive data captured in various stages of the menopausal transition. The remaining text reviews the contradictory… read more here.
Keywords: changes reproductive; aging perimenopause; cognitive changes; reproductive aging ... See more keywords
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction Update"
DOI: 10.1093/humupd/dmab038
Abstract: Abstract BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring. As the… read more here.
Keywords: age; cellular senescence; female reproductive; role ... See more keywords
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13349
Abstract: Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic… read more here.
Keywords: methylation; aging epigenetic; model; reproductive aging ... See more keywords
HLA‐DR+ CD45RAˉ Tregs and CD28ˉ Treg‐like cells: Potential immunologic biomarkers for reproductive aging
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13591
Abstract: This study aimed to identify subsets of regulatory T cells (Tregs) associated with ovarian aging and determine whether they can be used as markers of reproductive aging. read more here.
Keywords: cd28 treg; tregs cd28; hla cd45ra; treg like ... See more keywords
Abstract 226: Single variant and gene-based replication analysis of reproductive aging in African American women in the AMBER Consortium
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-226
Abstract: The two main hormonal events of a woman9s life, menarche and menopause, have a paramount impact on the duration of exposure to estrogen. Reproductive aging phenotypes, including age at menarche (AM) and age at natural… read more here.
Keywords: aging african; analysis; gene based; reproductive aging ... See more keywords
Aging and sperm signals alter DNA break formation and repair in the C. elegans germline
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010282
Abstract: Female reproductive aging is associated with decreased oocyte quality and fertility. The nematode Caenorhabditis elegans is a powerful system for understanding the biology of aging and exhibits age-related reproductive defects that are analogous to those… read more here.
Keywords: dna repair; repair elegans; formation; reproductive aging ... See more keywords
Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.718522
Abstract: Aging animals display a broad range of progressive degenerative changes, and one of the most fascinating is the decline of female reproductive function. In the model organism Caenorhabditis elegans, hermaphrodites reach a peak of progeny… read more here.
Keywords: caenorhabditis elegans; aging caenorhabditis; day adulthood; reproductive aging ... See more keywords
Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.782824
Abstract: The elderly males undergo degenerative fertility and testicular endocrine function that jeopardize the reproductive health and well-being. However, the mechanisms underlying reproductive aging are unclear. Here, we tried to address this by investigating the phenotypes… read more here.
Keywords: male mouse; mouse reproductive; system aging; male reproductive ... See more keywords
Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10040519
Abstract: Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects. However, the mechanisms underlying reproductive aging remain largely… read more here.
Keywords: supplementation; quality; oocyte quality; mitochondrial function ... See more keywords
The Role of PEDF in Reproductive Aging of the Ovary
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810359
Abstract: Reproductive aging is characterized by a decline in ovarian function and in oocytes’ quantity and quality. Pigment epithelium-derived factor (PEDF), a pivotal player in ovarian angiogenic and oxidative balance, was evaluated for its involvement in… read more here.
Keywords: pedf; aging ovary; rate; role pedf ... See more keywords