Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4749
Abstract: N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde,… read more here.
Keywords: reproductive developmental; transgenerational reproductive; toxicity; formaldehyde drosophila ... See more keywords
Reproductive and Developmental Toxicity Assessment of Palbociclib, a CDK4/6 Inhibitor, in Sprague-Dawley Rats and New Zealand White Rabbits.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2019.07.016
Abstract: Palbociclib is a selective inhibitor of the cyclin-dependent kinase (CDK) 4/6, approved for the treatment of breast cancer. We assessed the potential effects of oral administration of palbociclib on reproduction and development. There were no… read more here.
Keywords: palbociclib; inhibitor; toxicity; developmental toxicity ... See more keywords
Prediction of reproductive and developmental toxicity using an attention and gate augmented graph convolutional network
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DOI: 10.1038/s41598-025-02590-y
Abstract: Due to the diverse molecular structures of chemical compounds and their intricate biological pathways of toxicity, predicting their reproductive and developmental toxicity remains a challenge. Traditional Quantitative Structure-Activity Relationship models that rely on molecular descriptors… read more here.
Keywords: graph convolutional; reproductive developmental; toxicity; developmental toxicity ... See more keywords
Reproductive and developmental toxicity of α-terpineol in Wistar rats
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DOI: 10.1080/01480545.2024.2412022
Abstract: Abstract Alpha-terpineol (α-T) is a type of monoterpenoid alcohol commonly present in essential oils, it contributes to a pleasant floral fragrance similar to that of lilacs. This research aimed to evaluate the impact of α-terpineol… read more here.
Keywords: 300 day; 150 300; reproductive developmental; wistar rats ... See more keywords
Reproductive & developmental toxicity of quaternary ammonium compounds
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DOI: 10.1093/biolre/ioae107
Abstract: Abstract Quaternary ammonium compounds are a class of chemicals commonly used as disinfectants in household and healthcare settings. Their usage has significantly increased in recent years due to the COVID-19 pandemic. In addition, quaternary ammonium… read more here.
Keywords: reproductive developmental; ammonium compound; ammonium; quaternary ammonium ... See more keywords
The reproductive and developmental toxicity of nanoparticles: A bibliometric analysis
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DOI: 10.1177/0748233717744430
Abstract: Because of the advantages of nanoparticles (NPs) in a variety of industrial, biomedical, and consumer applications, they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human body. However, to date,… read more here.
Keywords: developmental toxicity; reproductive developmental; bibliometric analysis; toxicity nanoparticles ... See more keywords
Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals
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DOI: 10.1371/journal.pone.0172770
Abstract: 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated… read more here.
Keywords: developmental toxicity; hydroxypterostilbene; toxicity; day repeated ... See more keywords