Reproductive and Developmental Toxicity Assessment of Palbociclib, a CDK4/6 Inhibitor, in Sprague-Dawley Rats and New Zealand White Rabbits.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2019.07.016
Abstract: Palbociclib is a selective inhibitor of the cyclin-dependent kinase (CDK) 4/6, approved for the treatment of breast cancer. We assessed the potential effects of oral administration of palbociclib on reproduction and development. There were no… read more here.
Keywords: palbociclib; inhibitor; toxicity; developmental toxicity ... See more keywords
The reproductive and developmental toxicity of nanoparticles: A bibliometric analysis
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DOI: 10.1177/0748233717744430
Abstract: Because of the advantages of nanoparticles (NPs) in a variety of industrial, biomedical, and consumer applications, they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human body. However, to date,… read more here.
Keywords: developmental toxicity; reproductive developmental; bibliometric analysis; toxicity nanoparticles ... See more keywords
Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals
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DOI: 10.1371/journal.pone.0172770
Abstract: 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated… read more here.
Keywords: developmental toxicity; hydroxypterostilbene; toxicity; day repeated ... See more keywords