Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1601-7_1
Abstract: Forced expression of specific neuronal transcription factors in mouse embryonic fibroblasts (MEFs) can lead to their direct conversion into functional neurons. Direct neuronal reprogramming has become a powerful tool to characterize individual factors and molecular… read more here.
Keywords: isolation neuronal; embryonic fibroblasts; mouse embryonic; reprogramming ... See more keywords
Partial Reprogramming as a Method for Regenerating Neural Tissues in Aged Organisms
Sign Up to like & getrecommendations! Published in 2024 at "Cellular Reprogramming"
DOI: 10.1089/cell.2023.0123
Abstract: Aging causes numerous age-related diseases, leading the human species to death. Nevertheless, rejuvenating strategies based on cell epigenetic modifications are a possible approach to counteract disease progression while getting old. Cell reprogramming of adult somatic… read more here.
Keywords: reprogramming; reprogramming method; age related; cell ... See more keywords
Enhancing cellular regeneration through targeted pharmacological reprogramming of senescent endothelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvae088.141
Abstract: None. Senescent endothelial cells (EC) are key players in the pathophysiology of cardiovascular diseases and characterized by a reduced angiogenic and regenerative potential. Therefore, reversing EC senescence represents a promising therapeutic strategy to restore vascular… read more here.
Keywords: senescent endothelial; senescence; reprogramming; enhancing cellular ... See more keywords
Abstract 4366240: Transient pharmacological reprogramming reverses endothelial senescence and promotes vascular regeneration
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366240
Abstract: Endothelial cell (EC) senescence has been identified as a significant contributor to the development of cardiovascular disease, resulting in impaired angiogenesis and tissue regeneration. Consequently, the reversal of EC senescence emerges as a promising therapeutic… read more here.
Keywords: senescence; reprogramming; senescent ecs; transient pharmacological ... See more keywords
Long Live Partial Reprogramming.
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/circresaha.117.310594
Abstract: In vivo amelioration of age-associated hallmarks by partial reprogramming . Ocampo et al Cell. 2016;167:1719–1733. Aging can be defined as the progressive loss of physiological integrity that leads to tissue dysfunction and increased risk for… read more here.
Keywords: partial reprogramming; live partial; long live; age associated ... See more keywords
Decoding Aging through iPSC Reprogramming: Advances and Challenges.
Sign Up to like & getrecommendations! Published in 2025 at "Aging and disease"
DOI: 10.14336/ad.2025.0438
Abstract: Aging is characterized by cellular senescence and increased susceptibility to age-related diseases. Induced pluripotent stem cell (iPSC) technology demonstrates the potential to reverse aging hallmarks, including telomere attrition, mitochondrial dysfunction, and oxidative stress. Reprogramming somatic… read more here.
Keywords: reprogramming; advances challenges; aging ipsc; decoding aging ... See more keywords