Simultaneous reprogramming and gene editing of human fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Nature protocols"
DOI: 10.1038/nprot.2018.007
Abstract: The utility of human induced pluripotent stem cells (iPSCs) is enhanced by an ability to precisely modify a chosen locus with minimal impact on the remaining genome. However, the derivation of gene-edited iPSCs typically involves… read more here.
Keywords: gene editing; human fibroblasts; gene edited; simultaneous reprogramming ... See more keywords
Abstract 543: Clinical Development of Cardiac Reprogramming Gene Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.543
Abstract: Heart failure affects an estimated 38 million people worldwide and is typically caused by cardiomyocyte (CM) loss or dysfunction. Although CMs have limited ability to regenerate, a large pool of non-myocytes, including cardiac fibroblasts (CFs),… read more here.
Keywords: gene therapy; safety; cardiac reprogramming; cardiac ... See more keywords