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   Articles with "reprogramming human" as a keyword



High-efficiency RNA-based reprogramming of human primary fibroblasts

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-03190-3

Abstract: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that the synergistic activity of synthetic… read more here.

Keywords: medicine; primary fibroblasts; synergistic activity; reprogramming human ... See more keywords

Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts.

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recommendations! Published in 2022 at "Cellular reprogramming"

DOI: 10.1089/cell.2022.0014

Abstract: Reprogramming of human dermal fibroblasts (HDFs) into induced cardiomyocyte-like cells (iCMs) represents a promising strategy for human cardiac regeneration. Different cocktails of cardiac transcription factors can convert HDFs into iCMs, although with low efficiency and… read more here.

Keywords: dermal fibroblasts; gata4; stoichiometry; expression ... See more keywords

Roxadustat enhances inflammation and metabolic reprogramming in human leukocytes by affecting oxygen sensing.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkaf167

Abstract: Since its approval in 2019, hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, like roxadustat, have been used for treatment of anemia in chronic kidney disease. However, the impact of HIF stabilization on circulating leukocytes remains largely… read more here.

Keywords: metabolic reprogramming; roxadustat enhances; oxygen; reprogramming human ... See more keywords

Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models.

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recommendations! Published in 2024 at "Cold Spring Harbor perspectives in medicine"

DOI: 10.1101/cshperspect.a041552

Abstract: Stable isotope-resolved metabolomics delineates reprogrammed intersecting metabolic networks in human cancers. Knowledge gained from in vivo patient studies provides the "benchmark" for cancer models to recapitulate. It is particularly difficult to model patients' tumor microenvironment… read more here.

Keywords: cancer; metabolic reprogramming; patient derived; reprogramming human ... See more keywords