Reprogramming Immunosuppressive Niches and the Cancer Immunity Cycle in Pancreatic Cancer with Neoantigen mRNA Plus Immune Adjuvant Nanocarrier Strategies.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c14753
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal malignancies, driven by an immune-excluded, desmoplastic tumor microenvironment (TME), a low neoantigen burden, and resistance to immune checkpoint blockade. Recent progress in immunotherapy has emerged from… read more here.
Keywords: cancer; immunity; neoantigen; reprogramming immunosuppressive ... See more keywords
Reprogramming immunosuppressive tumour-associated dendritic cells with GADD45β inhibitors.
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DOI: 10.7861/clinmed.20-2-s116
Abstract: The ability of dendritic cells to present tumour antigens efficiently to cytotoxic T-cells has led to a continuous focus on exploiting their unique stimulatory abilities in therapeutic cancer vaccinations.[1][1] However, existing clinical strategies utilising dendritic… read more here.
Keywords: immunosuppressive tumour; tumour associated; associated dendritic; reprogramming immunosuppressive ... See more keywords