REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107591
Abstract: The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a limited understanding of the… read more here.
Keywords: endocrine genes; endocrine; reprogramming pancreatic; pdx1 ... See more keywords
Novel strategy for oncogenic alteration-induced lipid metabolism reprogramming in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2023045
Abstract: The pathogenesis of pancreatic cancer involves substantial metabolic reprogramming, resulting in abnormal proliferation of tumor cells. This tumorigenic reprogramming is often driven by genetic mutations, such as activating mutations of the KRAS oncogene and inactivating… read more here.
Keywords: pancreatic cancer; lipid metabolism; metabolism reprogramming; reprogramming pancreatic ... See more keywords