Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2020.114169
Abstract: Abstract On March 11, 2020, the World Health Organization (WHO) declared the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) a global pandemic. As of July 2020, SARS-CoV-2 has infected more than 14 million… read more here.
Keywords: disease 2019; mechanisms action; repurposed drugs; sars cov ... See more keywords
Computational identification of repurposed drugs against viruses causing epidemics and pandemics via drug-target network analysis
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104677
Abstract: Viral epidemics and pandemics are considered public health emergencies. However, traditional and novel antiviral discovery approaches are unable to mitigate them in a timely manner. Notably, drug repurposing emerged as an alternative strategy to provide… read more here.
Keywords: epidemics pandemics; drugs viruses; drug; causing epidemics ... See more keywords
Combining repurposed drugs to treat colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.09.012
Abstract: The drug development process, especially of antineoplastic agents, has become increasingly costly and ineffective. Drug repurposing and drug combination are alternatives to de novo drug development, being low cost, rapid, and easy to apply. These… read more here.
Keywords: colorectal cancer; drug; combining repurposed; drugs treat ... See more keywords
How nano-engineered delivery systems can help marketed and repurposed drugs in Alzheimer's disease treatment?
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.02.022
Abstract: Given the continual increase in the number of patients and the lack of curative treatment, the development of new therapies to treat Alzheimer's disease (AD) is becoming ever more urgent. In this review, we summarize… read more here.
Keywords: treatment; engineered delivery; repurposed drugs; alzheimer disease ... See more keywords
Impact of repurposed drugs on the symptomatic COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Infection and Public Health"
DOI: 10.1016/j.jiph.2020.11.009
Abstract: An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus capable of causing coronavirus disease 2019 (COVID-19), was declared as a global public health emergency on January 30, 2020, by the World… read more here.
Keywords: drugs symptomatic; covid; impact repurposed; repurposed drugs ... See more keywords
Advances in the Therapeutic Application of Small-Molecule Inhibitors and Repurposed Drugs against Snakebite.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00266
Abstract: The World Health Organization has declared snakebite as a neglected tropical disease. Antivenom administration is the sole therapy against venomous snakebite; however, several limitations of this therapy reinforce the dire need for an alternative and/or… read more here.
Keywords: small molecule; advances therapeutic; repurposed drugs; therapeutic application ... See more keywords
Potential Repurposed Drug Candidates for Tuberculosis Treatment: Progress and Update of Drugs Identified in Over a Decade
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c05511
Abstract: The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades. The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to 95% and 90% of overall TB… read more here.
Keywords: progress; drugs identified; repurposed drugs; repurposed drug ... See more keywords
A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122512119
Abstract: Significance This study aims to identify drugs that activate the Mullerian inhibiting substance pathway to be used for contraception or other applications in women’s health. We describe a high-throughput screening pipeline to identify small molecules… read more here.
Keywords: misr2 agonists; amhr2 misr2; identifies amhr2; drugs identifies ... See more keywords
DrugRepV: a compendium of repurposed drugs and chemicals targeting epidemic and pandemic viruses
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa421
Abstract: Viruses are responsible for causing various epidemics and pandemics with a high mortality rate e.g. ongoing SARS-CoronaVirus-2 crisis. The discovery of novel antivirals remains a challenge but drug repurposing is emerging as a potential solution… read more here.
Keywords: drugrepv compendium; drugs chemicals; repurposed drugs; database ... See more keywords
Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Science"
DOI: 10.1111/cts.12882
Abstract: The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because benefits are awaited, not proven. A thorough literature search… read more here.
Keywords: covid repurposed; risk; repurposed drugs; drug induced ... See more keywords
Perspectives on Repurposed Drugs Based on Globally Accepted Therapeutic Guidelines to Combat SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2021 at "Drug, Healthcare and Patient Safety"
DOI: 10.2147/dhps.s272411
Abstract: Abstract A beta coronavirus was identified in Wuhan, China, in December 2019 and was named severe acute respiratory syndrome coronavirus-2. It spread globally at a rapid rate and killed innumerable people. The SARS-CoV-2 infection, also… read more here.
Keywords: therapeutic guidelines; repurposed drugs; perspectives repurposed; sars cov ... See more keywords