Repurposing antidepressants for anticancer drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.10.019
Abstract: Drug repurposing is an attractive strategy for identifying new indications for existing drugs. Three approved antidepressants have advanced into clinical trials for cancer therapy. In particular, further medicinal chemistry efforts with tranylcypromine (TCP) have led… read more here.
Keywords: antidepressants anticancer; repurposing antidepressants; drug; anticancer drug ... See more keywords
Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases
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DOI: 10.3390/antibiotics12010137
Abstract: Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) that are responsible for extruding antimicrobial… read more here.
Keywords: infectious diseases; phenothiazine antipsychotics; development; repurposing antidepressants ... See more keywords