Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13‐cis‐Retinoic Acid is a PTP1B Inhibitor
Sign Up to like & getrecommendations! Published in 2024 at "Chemmedchem"
DOI: 10.1002/cmdc.202400452
Abstract: Current treatments for type 2 diabetes (T2D) mainly rely on exercise, dietary control, and anti‐diabetic drugs to enhance insulin secretion and improve insulin sensitivity. However, there is a need for more therapeutic options, as approved… read more here.
Keywords: retinoic acid; repurposing approach; ptp1b; cis retinoic ... See more keywords
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets
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DOI: 10.1002/med.21763
Abstract: In the past two decades, three highly pathogenic human coronaviruses severe acute respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome coronavirus, and, recently, SARS‐CoV‐2, have caused pandemics of severe acute respiratory diseases with alarming morbidity… read more here.
Keywords: approach combating; drug repurposing; combating coronavirus; drug ... See more keywords
In silico studies on therapeutic agents for COVID-19: Drug repurposing approach
Sign Up to like & getrecommendations! Published in 2020 at "Life Sciences"
DOI: 10.1016/j.lfs.2020.117652
Abstract: Abstract Aims The severe acute respiratory syndrome coronavirus 2, better known as COVID-19 has become the current health concern to the entire world. Initially appeared in Wuhan, China around December 2019, it had spread to… read more here.
Keywords: silico studies; drug repurposing; drug; studies therapeutic ... See more keywords
A novel computational drug repurposing approach for Systemic Lupus Erythematosus (SLE) treatment using Semantic Web technologies
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.03.068
Abstract: https://doi.org/10.1016/j.sjbs.2021.03.068 1319-562X/ 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). ⇑ Corresponding author at: Department of Clinical Pharmacy,… read more here.
Keywords: systemic lupus; drug repurposing; novel computational; computational drug ... See more keywords
The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Psychiatry"
DOI: 10.1038/s41380-024-02820-1
Abstract: Working memory (WM), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophrenia. Through a genome-guided drug repurposing approach, we identified fampridine, a potassium channel blocker used to improve walking… read more here.
Keywords: fampridine; working memory; genome guided; repurposing approach ... See more keywords
Unraveling PPARβ/δ nuclear receptor agonists via a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation
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DOI: 10.1039/d4ra09055a
Abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors with a crucial regulatory role in carbohydrate and lipid metabolism and are emerging druggable targets in “metabolic syndrome” (MetS) and cancers. However, there is a need to… read more here.
Keywords: drug repurposing; repurposing approach; anti steatotic; drug ... See more keywords
A novel drug repurposing approach for non-small cell lung cancer using deep learning
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DOI: 10.1371/journal.pone.0233112
Abstract: Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful… read more here.
Keywords: novel drug; drug repurposing; drug; cell ... See more keywords
Drug repurposing approach against chikungunya virus: an in vitro and in silico study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1132538
Abstract: The chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes mosquitoes. There are no licenced antivirals or vaccines for treatment or prevention. Drug repurposing approach has emerged as a novel concept to find alternative uses… read more here.
Keywords: chikungunya; repurposing approach; chikungunya virus; drug repurposing ... See more keywords