Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron.
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DOI: 10.1021/acschembio.1c00771
Abstract: We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O6 position of guanine (O6G) and is… read more here.
Keywords: fusion; degron; repurposing damage; guanine ... See more keywords