Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_3
Abstract: Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of… read more here.
Keywords: repurposing drugs; evolutionary relationships; drugs proteins; approved drugs ... See more keywords
Recycled Translation: Repurposing Drugs for Stroke.
Sign Up to like & getrecommendations! Published in 2022 at "Translational stroke research"
DOI: 10.1007/s12975-022-01000-z
Abstract: Stroke, which continues to be a leading cause of death and long-term disability worldwide, has often been described as a clinical graveyard. While multiple small molecule therapeutics have undergone clinical trials in stroke, currently only… read more here.
Keywords: drug; translation repurposing; recycled translation; repurposing drugs ... See more keywords
Repurposing of drugs approved for cardiovascular diseases: opportunity or mirage?
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113895
Abstract: Drug repurposing is a promising way in drug discovery to identify new therapeutic uses -different from the original medical indication- for existing drugs. It has many advantages over traditional approaches to de novo drug discovery,… read more here.
Keywords: repurposing drugs; drugs approved; cardiovascular diseases; drug ... See more keywords
Repurposing drugs as COVID-19 therapies: A toxicity evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Discovery Today"
DOI: 10.1016/j.drudis.2022.04.001
Abstract: Drug repurposing is an appealing method to address the Coronavirus 2019 (COVID-19) pandemic because of their low cost and efficiency. We analyzed our in-house database of approved drug screens and compared their activity profiles with… read more here.
Keywords: repurposing drugs; anti sars; drug; toxicity ... See more keywords
Repurposing drugs for the management of COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2021.1861248
Abstract: ABSTRACT Introduction: The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents a serious health issue worldwide, with more than 61 million cases and more than 1.4 million deaths since the beginning of the epidemic near… read more here.
Keywords: repurposing drugs; management covid; drug repurposing; drug ... See more keywords
Repurposing drugs for the treatment of galactosemia
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Orphan Drugs"
DOI: 10.1080/21678707.2019.1672533
Abstract: ABSTRACT Introduction: Galactosemia results from mutations in genes which code for enzymes involved in the metabolism of galactose. It has a wide range of symptoms ranging from the relatively mild (early onset cataracts) to severe… read more here.
Keywords: treatment galactosemia; repurposing drugs; galactosemia; treatment ... See more keywords
Repurposing of drugs targeting the cytokine storm induced by SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15987
Abstract: A cytokine storm is one of the leading causes of acute respiratory distress syndrome (ARDS) and sepsis‐associated multiple organ failure in many respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The coronavirus… read more here.
Keywords: repurposing drugs; cytokine storm; sars cov; drugs targeting ... See more keywords
Rapid repurposing of drugs for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb9332
Abstract: The emergence of a new coronaviral respiratory disease calls for repurposing existing drugs In late fall 2019, a novel acute respiratory disease, called coronavirus disease 2019 (COVID-19) emerged in Wuhan, China. COVID-19 is caused by… read more here.
Keywords: repurposing drugs; acute respiratory; covid; drugs covid ... See more keywords
Repurposing Drugs for the Treatment of COVID-19 and Its Cardiovascular Manifestations
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DOI: 10.1161/circresaha.122.321879
Abstract: COVID-19 is an infectious disease caused by SARS-CoV-2 leading to the ongoing global pandemic. Infected patients developed a range of respiratory symptoms, including respiratory failure, as well as other extrapulmonary complications. Multiple comorbidities, including hypertension,… read more here.
Keywords: drug repositioning; covid; repurposing drugs; cardiovascular manifestations ... See more keywords
Repurposing drugs in oncology (ReDO)—selective PDE5 inhibitors as anti-cancer agents
Sign Up to like & getrecommendations! Published in 2018 at "ecancermedicalscience"
DOI: 10.3332/ecancer.2018.824
Abstract: Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were… read more here.
Keywords: repurposing drugs; redo selective; drugs oncology; oncology redo ... See more keywords
Pharmacological Efficacy of Repurposing Drugs in the Treatment of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044154
Abstract: Worldwide, prostate cancer (PC) is the second most frequent cancer among men and the fifth leading cause of death; moreover, standard treatments for PC have several issues, such as side effects and mechanisms of resistance.… read more here.
Keywords: prostate cancer; pharmacological efficacy; repurposing drugs; treatment ... See more keywords