Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01592-6
Abstract: Cancer cell expression of PD-L1 leads to T cells exhaustion by transducing co-inhibitory signal, and further understanding the regulation of PD-L1 in cancer cells may provide additional therapeutic strategies. Here by drug repurposing screen, we… read more here.
Keywords: degradation; identifies amlodipine; screen identifies; repurposing screen ... See more keywords
#2263 Computational drug repurposing screen targeting PLA2R antibody binding
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.282
Abstract: Approximately 60% of patients with membranous nephropathy have antibodies against the phospholipase A2 receptor (PLA2R). The cysteine rich (CysR) epitope of PLA2R is a likely site of protein-antibody interaction. Current treatment regimens for membranous nephropathy… read more here.
Keywords: antibody; membranous nephropathy; repurposing screen; drug ... See more keywords