SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017115118
Abstract: Significance Tumor development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we established a genetically tractable model, demonstrating that the same gene is relevant both cell autonomously… read more here.
Keywords: sox2 required; tumorigenesis; required independently; cell ... See more keywords