IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
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DOI: 10.1158/0008-5472.can-15-1684
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here, we show that the noncanonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation. Loss of IKBKE… read more here.
Keywords: kras induced; ikbke required; pancreatic tumorigenesis; induced pancreatic ... See more keywords