Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.02.010
Abstract: HIGHLIGHTSMeCP2 in the adult hippocampus is required for long‐term memory formation.MeCP2 maintains the chromatin features of mature CA1 neurons.MeCP2 preserves the genomic responsiveness to hippocampus‐dependent learning. ABSTRACT MeCP2 is required both during postnatal neurodevelopment and… read more here.
Keywords: adult; hippocampus; long term; mecp2 ... See more keywords
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28301-z
Abstract: The pruning of dendritic spines during development requires autophagy. This process is facilitated by long-term depression (LTD)-like mechanisms, which has led to speculation that LTD, a fundamental form of synaptic plasticity, also requires autophagy. Here,… read more here.
Keywords: synaptic plasticity; long term; required long; depression ... See more keywords