Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09185-y
Abstract: How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases… read more here.
Keywords: required proper; nuclear lamina; lamina integrity; integrity required ... See more keywords
SUN-114 Microglia Interact with Hypothalamic Progenitors during Development and Are Required for Proper Energy Balance
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-114
Abstract: Abstract Microglia are the resident mononuclear phagocytic immune cells of the central nervous system (CNS), and are primarily responsible for responding to neural insults and disposing of cellular debris. However, over the last decade studies… read more here.
Keywords: development; brain; energy balance; required proper ... See more keywords
Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.677543
Abstract: Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof–/–) mice over the course of 48 weeks. We found otoferlin… read more here.
Keywords: required proper; outer hair; proper synapse; otoferlin required ... See more keywords