Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.
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DOI: 10.1021/acs.jmedchem.4c00333
Abstract: While in the process of designing more effective synthetic opioid rescue agents, we serendipitously identified a new chemotype of potent synthetic opioid. Here, we report that conformational constraint of a piperazine ring converts a mu… read more here.
Keywords: opioid rescue; rescue agents; synthetic opioid; respiratory depression ... See more keywords